IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of innate and adaptive immunity. Besides its established role in controlling homeostatic proliferation and survival of memory CD8+ T cells and natural killer cells, recent findings demonstrate that inflammatory IL-15 can also stimulate a variety of effector functions, such as enhanced cytotoxicity, entry into the cell cycle, and trafficking into non-lymphoid tissues. Here, we discuss how IL-15 is critical in regulating many functions of memory CD8+ T cells and how these processes act collectively to ensure optimal protective cellular immunity against re-infections.

中文翻译：

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通过IL-15控制记忆CD8 + T细胞寿命和效应子功能。

IL-15是常见的细胞因子伽马链家族的成员，并且在调节先天性和适应性免疫的多个方面起着重要作用。除了其在控制记忆CD8 + T细胞和自然杀伤细胞的稳态增殖和存活中已确立的作用外，最新发现还表明，炎症性IL-15还可以刺激多种效应子功能，例如增强的细胞毒性，进入细胞周期和运输进入非淋巴组织。在这里，我们讨论IL-15如何在调节记忆CD8 + T细胞的许多功能中起关键作用，以及这些过程如何共同起作用以确保针对再感染的最佳保护性细胞免疫。