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Outstanding insecticidal activity and sublethal effects of Carlina acaulis root essential oil on the housefly, Musca domestica, with insights on its toxicity on human cells.
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2019-12-07 , DOI: 10.1016/j.fct.2019.111037 Roman Pavela 1 , Filippo Maggi 2 , Riccardo Petrelli 2 , Loredana Cappellacci 2 , Michela Buccioni 2 , Alessandro Palmieri 3 , Angelo Canale 4 , Giovanni Benelli 4
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2019-12-07 , DOI: 10.1016/j.fct.2019.111037 Roman Pavela 1 , Filippo Maggi 2 , Riccardo Petrelli 2 , Loredana Cappellacci 2 , Michela Buccioni 2 , Alessandro Palmieri 3 , Angelo Canale 4 , Giovanni Benelli 4
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Carlina acaulis (Compositae) is traditionally used for food and medicinal purposes in central and southern Europe. Its root essential oil (EO), mainly composed by carlina oxide, is included in the BELFRIT botanical list of food supplements. It is also recognized as a potent mosquito larvicide. It is matter of concern whether this EO could be endowed with intrinsic toxicity to limit its use on a food level. Focusing on the insecticidal activity of this EO, we investigated the acute toxicity and sublethal effects on Musca domestica. In topical assays, the EO was extremely effective (LD50 = 2.74 and 5.96 μg fly-1, on males and females, respectively). The exposure to a sublethal dose (LD30) led to significant reductions of female longevity (LT50 = 6.7-9.0 days vs. control LT50 = 12.9-13.7 days). Treated females laid 2.5 times fewer eggs over control ones. F1 vitality decreased: F1 larvae and pupae showed high mortality, 2-4-fold higher over the control. The EO also showed high cytotoxicity on normal human fibroblasts (NHF-A12, IC50 = 9.4-14.2 μg mL-1 after 6-48 h). Overall, our findings support the employ of this EO for developing botanical insecticides. At the same time, they encourage food safety authorities to perform a full toxicological assessment for possible restrictions at food level.
中文翻译：
千里香树根精油对家蝇Musca domestica的优异杀虫活性和亚致死作用，并对其对人体细胞的毒性具有深刻的见解。
Carlina acaulis（菊科）传统上在中欧和南欧用于食品和医药目的。它的根精油（EO）主要由氧化碳构成，被列入BELFRIT植物性食品补充剂清单中。它也被认为是有效的蚊虫杀幼虫剂。令人关注的是，该EO是否可被赋予固有毒性以限制其在食品水平上的使用。着眼于该EO的杀虫活性，我们研究了对家蝇的急性毒性和亚致死作用。在局部测定中，EO非常有效（分别对雄性和雌性的LD50 = 2.74和5.96μgfly-1）。暴露于亚致死剂量（LD30）会导致女性寿命显着降低（LT50 = 6.7-9.0天，而对照组LT50 = 12.9-13.7天）。接受治疗的雌性产下2。比对照鸡蛋少5倍。F1活力下降：F1幼虫和p显示出高死亡率，比对照组高2-4倍。EO对正常的人类成纤维细胞也显示出高细胞毒性（6-48小时后，NHF-A12，IC50 = 9.4-14.2μgmL-1）。总的来说，我们的发现支持了该EO在植物性杀虫剂开发中的应用。同时，他们鼓励食品安全部门对食品中可能存在的限制进行全面的毒理学评估。
更新日期：2019-12-07
中文翻译：
千里香树根精油对家蝇Musca domestica的优异杀虫活性和亚致死作用，并对其对人体细胞的毒性具有深刻的见解。
Carlina acaulis（菊科）传统上在中欧和南欧用于食品和医药目的。它的根精油（EO）主要由氧化碳构成，被列入BELFRIT植物性食品补充剂清单中。它也被认为是有效的蚊虫杀幼虫剂。令人关注的是，该EO是否可被赋予固有毒性以限制其在食品水平上的使用。着眼于该EO的杀虫活性，我们研究了对家蝇的急性毒性和亚致死作用。在局部测定中，EO非常有效（分别对雄性和雌性的LD50 = 2.74和5.96μgfly-1）。暴露于亚致死剂量（LD30）会导致女性寿命显着降低（LT50 = 6.7-9.0天，而对照组LT50 = 12.9-13.7天）。接受治疗的雌性产下2。比对照鸡蛋少5倍。F1活力下降：F1幼虫和p显示出高死亡率，比对照组高2-4倍。EO对正常的人类成纤维细胞也显示出高细胞毒性（6-48小时后，NHF-A12，IC50 = 9.4-14.2μgmL-1）。总的来说，我们的发现支持了该EO在植物性杀虫剂开发中的应用。同时，他们鼓励食品安全部门对食品中可能存在的限制进行全面的毒理学评估。
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