Acrylamide is included on the State of California's Proposition 65 list as a carcinogen. Acrylamide is found in cigarette smoke and in many types of foods, including breads, cereals, coffee, cookies, French fries, and potato chips. In 1990, California's Office of Environmental Health Hazard Assessment (OEHHA) established a no significant risk level (NSRL) of 0.2 μg/day for acrylamide. Since then, multiple cancer studies have been published. In this report, we developed an updated NSRL for acrylamide. Using benchmark dose modeling and a weight-of-evidence, non-threshold approach to identify the most sensitive species, cancer slope factors (CSFs) were derived based on combined incidences of statistically significant neoplastic lesions in the Harderian gland, lung, and stomach in male mice. We then used a toxicokinetic (TK)-based scaling approach to convert the animal CSF to a human equivalent CSF, which served as the basis for the NSRL of 1.1 μg/day at the cancer risk level of 1 in 100,000. This NSRL can be used in quantitative exposure assessments to assess compliance with Proposition 65 to ascertain either the need for or exemption from the Proposition 65 labeling requirement and drinking water discharge prohibition.

中文翻译：

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丙烯酰胺无显着风险水平 (NSRL) 的推导

丙烯酰胺被列为加州 65 号提案的致癌物质。丙烯酰胺存在于香烟烟雾和多种食物中，包括面包、麦片、咖啡、饼干、炸薯条和薯片。1990 年，加利福尼亚州环境健康危害评估办公室 (OEHHA) 将丙烯酰胺的无显着风险水平 (NSRL) 确定为 0.2 微克/天。从那以后，发表了多项癌症研究。在本报告中，我们为丙烯酰胺开发了更新的 NSRL。使用基准剂量模型和证据权重、非阈值方法来识别最敏感的物种，根据哈德氏腺、肺和胃中具有统计学意义的肿瘤病变的综合发生率推导出癌症斜率因子 (CSF)。雄性老鼠。然后，我们使用基于毒代动力学 (TK) 的缩放方法将动物脑脊液转换为人体等效脑脊液，这是 100,000 分之一的癌症风险水平下 1.1 μg/天的 NSRL 的基础。该 NSRL 可用于定量暴露评估，以评估对 65 号提案的遵守情况，以确定是否需要或免除 65 号提案的标签要求和饮用水排放禁令。