Excessive glutamate release by glioma cells induces pharmacologically accessible neuronal hyperexcitation, including epilepsy. Two recent reports by Venkataramani et al. and Venkatesh et al. suggest that neuronal hyperexcitation stimulates bona fide glutamatergic synapses on glioma cells. Ionotropic glutamate receptors activate intercellular calcium signaling networks to orchestrate glioma cell growth and invasion, presumably by facilitating oncogenic signaling cascades and cytoskeletal remodeling.

中文翻译：

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神经元活动促进神经胶质瘤进展吗？

胶质瘤细胞过量释放谷氨酸导致药理学上可及的神经元过度兴奋，包括癫痫。Venkataramani等人的两个最新报告。和Venkatesh等。提示神经元过度兴奋会刺激神经胶质瘤细胞上的真正的谷氨酸能突触。离子型谷氨酸受体激活细胞间钙信号网络来协调神经胶质瘤细胞的生长和侵袭，大概是通过促进致癌信号级联和细胞骨架重塑来实现的。