Diastereoselective Synthesis of Functionalized Indoline N,O‐Aminals: Unexpected Water‐Involved Cascade Reaction of 3H‐Indoles and Oxazol‐5‐(4H)ones,European Journal of Organic Chemistry

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Diastereoselective Synthesis of Functionalized Indoline N,O‐Aminals: Unexpected Water‐Involved Cascade Reaction of 3H‐Indoles and Oxazol‐5‐(4H)ones
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-01-14 , DOI: 10.1002/ejoc.201901774
Dao-Juan Cheng ₁ , Rui-Qi Li ₁ , Xing-Shuai Zhang ₁ , Lin Zhao ₁ , Tao Wang ₁ , You-Dong Shao ₁

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A Brønsted acid catalyzed highly diastereoselective three‐component cascade reaction of 3H‐indoles, oxazol‐5‐(4H)ones and water is reported. The reaction proceeds under mild conditions with broad substrate scope to give the desired products in high yields.