BACKGROUND Current guidance from International Society for Heart and Lung Transplantation recommends using body weight for donor-recipient size matching for heart transplantation. However, recent studies have shown that predicted heart mass, using body weight, height, age, and sex, may represent a better method of size matching. We aim to validate a cardiovascular magnetic resonance (CMR)-derived equation for predicted left ventricular mass (LVM) in a cohort of normal individuals in the United Kingdom. METHODS This observational study was conducted in 5065 middle-aged (44-77 years old) UK Biobank participants who underwent CMR imaging in 2014 to 2015. Individuals with cancer diagnosis in the previous 12 months or history of cardiovascular disease were excluded. Predicted LVM was calculated based on participants' sex, height, and weight recorded at the time of imaging. Correlation analyses were performed between the predicted LVM and the LVM obtained from manual contouring of CMR cine images. The analysis included 3398 participants (age 61.5±7.5 years, 47.8% males). RESULTS Predicted LVM was considerably higher than CMR-derived LVM (mean±SD of 138.8±28.9 g versus 86.3±20.9 g). However, there was a strong correlation between the 2 measurements (Spearman correlation coefficient 0.802, P<0.0001). CONCLUSIONS Predicted LVM calculated using a CMR-derived equation that incorporates height, weight, and sex has a strong correlation with CMR LVM in large cohort of normal individuals in the United Kingdom. Our findings suggest that predicted heart mass equations may be a valid tool for donor-recipient size matching for heart transplantation in the United Kingdom.

中文翻译：

---

使用UK Biobank成像队列验证心血管磁共振衍生方程对左心室质量的预测：供体-受体大小匹配的工具。

背景技术国际心脏和肺移植协会的当前指南建议使用体重进行心脏移植的供体-受体大小匹配。但是，最近的研究表明，使用体重，身高，年龄和性别来预测心脏质量可能代表一种更好的尺寸匹配方法。我们旨在验证英国正常人群中预测左心室质量（LVM）的心血管磁共振（CMR）方程。方法这项观察性研究是在5065名2014年至2015年接受CMR成像的中年（44-77岁）英国Biobank参与者中进行的。排除了在过去12个月内有癌症诊断或心血管病史的患者。预测的LVM是根据参与者的性别，身高，成像时记录的重量和重量。在预测的LVM和从CMR电影图像的手动轮廓获得的LVM之间进行了相关分析。该分析包括3398名参与者（年龄61.5±7.5岁，男性47.8％）。结果预测的LVM显着高于CMR衍生的LVM（平均值±SD为138.8±28.9 g，而86.3±20.9 g）。但是，两次测量之间存在很强的相关性（Spearman相关系数0.802，P <0.0001）。结论在英国的正常人群中，使用CMR派生的方程（包括身高，体重和性别）计算的预测LVM与CMR LVM有很强的相关性。我们的研究结果表明，预测的心脏质量方程式可能是英国心脏移植中供体-受体大小匹配的有效工具。