The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents.,PLOS Biology

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The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents.
PLOS Biology ( IF 7.8 ) Pub Date : 2019-12-05 , DOI: 10.1371/journal.pbio.3000482
Thomas M McGrath _{1,

2} , Eleanor Spreckley ₃ , Aina Fernandez Rodriguez ₃ , Carlo Viscomi ₄ , Amin Alamshah ₃ , Elina Akalestou ₃ , Kevin G Murphy ₃ , Nick S Jones _{1,

2}

Affiliation

Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analysing the different effects on feeding behaviour of peptide YY3-36 (PYY3-36), lithium chloride, glucagon-like peptide 1 (GLP-1), and leptin shows the precise behavioural changes caused by each anorectic agent. Our analysis demonstrates that the changes in feeding behaviour evoked by the anorectic agents investigated do not mimic the behaviour of well-fed animals and that the intermeal interval is influenced by fullness. We show how robust homeostatic control of feeding thwarts attempts to reduce food intake and how this might be overcome. In silico experiments suggest that introducing a minimum intermeal interval or modulating upper gut emptying can be as effective as anorectic drug administration.

中文翻译：

进食行为的稳态动力学确定了厌食剂的新机制。

更好地了解喂养行为对于减少肥胖和代谢综合征至关重要，但我们缺乏一个标准模型来捕捉喂养行为的复杂性。我们在回合级别构建了一个准确的啮齿动物喂养随机模型，以便进行定量行为分析。分析肽 YY3-36 (PYY3-36)、氯化锂、胰高血糖素样肽 1 (GLP-1) 和瘦素对进食行为的不同影响显示了每种厌食剂引起的精确行为变化。我们的分析表明，所研究的厌食剂引起的进食行为的变化并不模仿喂食良好的动物的行为，并且餐间间隔受饱腹感的影响。我们展示了强有力的喂养稳态控制如何阻止减少食物摄入的尝试，以及如何克服这一点。计算机实验表明，引入最小的餐间间隔或调节上消化道排空与厌食药物给药一样有效。

更新日期：2019-12-06

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