Nickel(II)-catalyzed C–C, N–C cascade coupling of ketonitriles into substituted pyrroles and pyridines,Organic Chemistry Frontiers

当前位置： X-MOL 学术 › Org. Chem. Front. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Nickel(II)-catalyzed C–C, N–C cascade coupling of ketonitriles into substituted pyrroles and pyridines
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2019/12/06 , DOI: 10.1039/c9qo01259a
Qianqian Zhen _{1,

2,

3,

4} , Renhao Li _{3,

4,

5,

6} , Linjun Qi _{1,

2,

3,

4} , Kun Hu _{1,

2,

3,

4} , Xinrong Yao _{1,

2,

3,

4} , Yinlin Shao _{1,

2,

3,

4} , Jiuxi Chen _{1,

2,

3,

4}

Affiliation

We have demonstrated the first ever example of nickel complexes as effective catalysts to promote the C–C, N–C cascade coupling of ketonitriles with arylboronic acids, affording potentially biologically active 3-carboxylate-2,5-diaryl-pyrroles as well as 2,5-diarylpyrroles and 2,6-diarylpyridines. This protocol features a broad scope of substrates and excellent functional group tolerance, thus representing a highly versatile and atom-economical alternative to novel methods for the synthesis of various unsymmetrical diarylpyrroles and diarylpyridines under manageable conditions.

中文翻译：

镍（II）催化的乙腈的CC，NC级联偶联成取代的吡咯和吡啶

我们已经证明了镍络合物作为促进乙腈与芳基硼酸的C–C，N–C级联偶联的有效催化剂的第一个实例，可提供具有潜在生物活性的3-羧酸盐-2,5-二芳基-吡咯以及2 1，5-二芳基吡咯和2，6-二芳基吡啶。该方案具有广泛的底物范围和出色的官能团耐受性，因此代表了在可控条件下合成各种不对称二芳基吡咯和二芳基吡啶的新颖方法的高度通用和原子经济的替代方法。

更新日期：2020-02-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11