Background Allergic respiratory diseases such as allergic rhinitis (AR) and allergic asthma (AA) are common conditions that can influence sleep and daytime functioning. However, the significance of this impact is unclear-particularly in perennial allergy sufferers. This study investigates the impact of perennial allergy on sleep, daily activities and productivity. Methods Adults with self-reported or physician-diagnosed perennial AR aged ≥ 18 years were recruited in Denmark, France, Germany and Sweden. Allergy sufferers were identified using online panels closely matching national population characteristics for each country. Impact on sleep, work, productivity and activity (by the Work, Productivity and Activity Index) were analysed. Descriptive analyses were conducted. Results In total, 511 subjects with perennial AR (47.4% also with seasonal allergy) completed the survey. Most subjects (77.5%) had a physician-diagnosis of AR; 46.4% were diagnosed with both AA and AR. Most subjects (65.2%) reported sensitisation to house dust mites. Of all subjects, 66.0% reported sleep problems. Subjects with sleep problems woke, on average, 3.8 times per night, with 92.0% taking 15+ min to fall asleep (22.2% took 60+ min). Upon waking at night, 40.8% struggled to get back to sleep, and 69.2% had difficulties waking in the morning due to tiredness. Disturbances in daily functioning due to sleep issues were reported in 85.5-95.0% of subjects with sleep problems across all aspects investigated. Overall work and activity impairment were 53.3% and 47.1%, respectively. Sleep issues were more frequent (78.1% vs 54.7%) in those diagnosed with both AR and AA compared to AR alone, and more burdensome, with a greater impact on daily functioning (47.0% vs 33.3%) and impairment in work and activity (62.0% and 54.9% vs 39.3% and 35.2%, respectively). Of all subjects, 20.5% were receiving AIT at the time of the survey; of these, 36.4% reported moderate or great improvement in sleep due to allergy treatment. Conclusions In perennial AR sufferers, sleep problems are common and impact on daily functioning, with results indicating a greater burden in those with both AR and AA compared to AR alone.

中文翻译：

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常年性变应性鼻炎伴/不伴有变应性哮喘对睡眠，工作和活动水平的影响。

背景技术过敏性呼吸系统疾病，例如过敏性鼻炎（AR）和过敏性哮喘（AA），是会影响睡眠和白天功能的常见疾病。然而，这种影响的重要性尚不清楚，尤其是在常年性变态反应患者中。这项研究调查了常年性过敏对睡眠，日常活动和生产力的影响。方法在丹麦，法国，德国和瑞典招募具有自我报告或医生诊断的常年AR≥18岁的成年人。使用在线面板确定过敏患者，这些面板与每个国家的国家人口特征紧密匹配。分析了对睡眠，工作，生产力和活动的影响（通过工作，生产力和活动指数）。进行描述性分析。结果共有511名常年性AR患者（47。4％的人还因季节性过敏）完成了调查。大多数受试者（77.5％）具有AR的医生诊断。诊断为AA和AR的占46.4％。大多数受试者（65.2％）报告对屋尘螨过敏。在所有受试者中，有66.0％的人报告有睡眠问题。有睡眠问题的受试者平均每晚醒来3.8次，其中92.0％的人需要15分钟以上才能入睡（22.2％的人需要60分钟以上才能入睡）。晚上醒来时，有40.8％的人难以入睡，而69.2％的人由于疲倦而难以在早晨醒来。据报道，在所有调查的睡眠障碍患者中，有85.5-95.0％的人由于睡眠问题而导致了日常功能紊乱。总体工作和活动障碍分别为53.3％和47.1％。与单纯AR相比，AR和AA同时被诊断的人的睡眠问题更为频繁（分别为78.1％和54.7％），负担更大，对日常功能的影响更大（分别为47.0％和33.3％）和工作和活动障碍（分别为62.0％和54.9％和39.3％和35.2％）。在调查时，所有受试者中有20.5％接受了AIT。其中有36.4％的人由于过敏治疗而报告了适度或极大的睡眠改善。结论在常年性AR患者中，睡眠问题很普遍，并且会影响日常功能，结果表明与单独使用AR相比，AR和AA患者的负担都更大。