In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.

中文翻译：

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将目光投向传染病。

2019 年 5 月，英国邓迪大学威康抗感染研究中心 (WCAIR) 举行了一次国际会议，旨在讨论一些关键问题，围绕发现传染病新药，特别关注影响低血糖的疾病。和中等收入国家。迫切需要治疗大多数传染病的新药。我们很想看看是否有我们可以在不同疾病领域以及临床前和临床阶段之间学习的经验教训，目的是探索我们如何改进和加速药物发现、转化和临床开发过程。我们从一个关于当前情况的介绍性会议开始，然后从临床开发到联合治疗、药代动力学/药效学 (PK/PD) 研究，药物发现途径，以及新的起点和目标。这个观点旨在捕捉一些经验教训。