Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis.,Aging Cell

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Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis.
Aging Cell ( IF 8.0 ) Pub Date : 2019-12-05 , DOI: 10.1111/acel.13083
Camilla S L Tuttle ₁ , Mariette E C Waaijer ₂ , Monique S Slee-Valentijn ₃ , Theo Stijnen ₄ , Rudi Westendorp ₅ , Andrea B Maier _{1,

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Affiliation

Senescent cells in tissues and organs are considered to be pivotal to not only the aging process but also the onset of chronic disease. Accumulating evidence from animal experiments indicates that the magnitude of senescence can vary within and between aged tissue samples from the same animal. However, whether this variation in senescence translates across to human tissue samples is unknown. To address this fundamental question, we have conducted a systematic review and meta‐analysis of all available literature investigating the magnitude of senescence and its association with chronological age in human tissue samples. While senescence is higher in aged tissue samples, the magnitude of senescence varies considerably depending upon tissue type, tissue section, and marker used to detect senescence. These findings echo animal experiments demonstrating that senescence levels may vary between organs within the same animal.

中文翻译：

各种人体组织的细胞衰老和按年龄排序：系统综述和荟萃分析。

组织和器官中的衰老细胞不仅对衰老过程至关重要，而且对慢性疾病的发作也至关重要。来自动物实验的越来越多的证据表明，衰老的幅度可以在同一动物的老化组织样本内和之间发生变化。但是，这种衰老的变化是否会转化为人类组织样品尚不清楚。为了解决这个基本问题，我们对所有现有文献进行了系统的综述和荟萃分析，这些文献调查了人体组织样本中衰老的程度及其与年龄的关系。尽管衰老的组织样品中的衰老较高，但衰老的幅度因组织类型，组织切片和用于检测衰老的标记物而异。

更新日期：2019-12-05

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