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Molecular organization, regulation and function of tricellular junctions.
Biochimica et Biophysica Acta (BBA) - Biomembranes ( IF 2.8 ) Pub Date : 2019-12-06 , DOI: 10.1016/j.bbamem.2019.183143
Tomohito Higashi 1 , Hideki Chiba 1
Affiliation  

Tricellular junctions are specialized cell-cell junctions formed at sites where three epithelial or endothelial cells make contact at their apical side. By holding three cells together, tricellular junctions contribute to the maintenance of epithelial barrier function and mechanical integrity. In addition, recent studies have uncovered new functions of tricellular junctions at both cellular and physiological levels. In this review, we describe the architecture and molecular components of tricellular junctions and discuss how tricellular junctions participate in various biological processes.

中文翻译:

三细胞连接的分子组织,调控和功能。

三细胞接头是在三个上皮细胞或内皮细胞在其顶端接触的部位形成的专门的细胞-细胞接头。通过将三个细胞保持在一起,三细胞连接有助于维持上皮屏障功能和机械完整性。另外,最近的研究发现了在细胞和生理水平上三细胞连接的新功能。在这篇综述中,我们描述了三细胞连接的结构和分子成分,并讨论了三细胞连接如何参与各种生物过程。
更新日期:2019-12-06
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