Fungi can cause disease in humans, from mucocutaneous to life-threatening systemic infections. Initiation of antifungal immunity involves fungal recognition by pattern recognition receptors such as C-type lectin receptors (CLRs). These germline-encoded receptors trigger a multitude of innate responses including phagocytosis, fungal killing, and antigen presentation which can also shape the development of adaptive immunity. Recently, studies have shed light on how CLRs directly or indirectly modulate lymphocyte function. Moreover, CLR-mediated recognition of commensal fungi maintains homeostasis and prevents invasion from opportunistic commensals. We present an overview of current knowledge of antifungal T cell immune responses, with emphasis on the role of C-type lectins, and discuss how these receptors modulate these responses at different levels.

中文翻译：

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T 细胞抗真菌免疫和 C 型凝集素受体的作用。

真菌可引起人类疾病，从皮肤粘膜感染到危及生命的全身感染。抗真菌免疫的启动涉及模式识别受体如 C 型凝集素受体 (CLR) 对真菌的识别。这些种系编码受体触发多种先天反应，包括吞噬作用、真菌杀伤和抗原呈递，这些反应也可以影响适应性免疫的发展。最近，研究揭示了 CLR 如何直接或间接调节淋巴细胞功能。此外，CLR 介导的共生真菌识别可维持体内平衡并防止机会共生菌的入侵。我们概述了当前抗真菌 T 细胞免疫反应的知识，重点介绍了 C 型凝集素的作用，并讨论了这些受体如何在不同水平上调节这些反应。