Comprehensive cataloguing of the acute myeloid leukaemia (AML) genome has revealed a high frequency of mutations and deletions in epigenetic factors that are frequently linked to treatment resistance and poor patient outcome. In this review, we discuss how the epigenetic mechanisms that underpin normal haematopoiesis are subverted in AML, and in particular how these processes are altered in childhood and adolescent leukaemias. We also provide a brief summary of the burgeoning field of epigenetic-based therapies, and how AML treatment might be improved through provision of better conceptual frameworks for understanding the pleiotropic molecular effects of epigenetic disruption.

中文翻译：

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小儿急性骨髓性白血病的表观遗传学。

急性髓细胞性白血病（AML）基因组的全面分类显示，高频率的表观遗传因子突变和缺失与治疗抵抗力和患者预后不良相关。在这篇综述中，我们讨论了在AML中如何颠覆支撑正常造血功能的表观遗传机制，特别是在儿童和青少年白血病中如何改变这些过程。我们还简要介绍了基于表观遗传学的治疗方法的新兴领域，以及如何通过提供更好的概念框架来理解表观遗传学破坏的多效性分子效应来改善AML治疗。