Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction,Nanoscale Advances

当前位置： X-MOL 学术 › Nanoscale Adv. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction
Nanoscale Advances ( IF 4.6 ) Pub Date : 2019/12/05 , DOI: 10.1039/c9na00615j
Ana M Matos _{1,

2} , Ana I Gonçalves _{1,

2} , Alicia J El Haj ₃ , Manuela E Gomes _{1,

2,

4}

Affiliation

Tendon tissues connect muscle to bone allowing the transmission of forces resulting in joint movement. Tendon injuries are prevalent in society and the impact on public health is of utmost concern. Thus, clinical options for tendon treatments are in demand, and tissue engineering aims to provide reliable and successful long-term regenerative solutions. Moreover, the possibility of regulating cell fate by triggering intracellular pathways is a current challenge in regenerative medicine. In the last decade, the use of magnetic nanoparticles as nano-instructive tools has led to great advances in diagnostics and therapeutics. Recent advances using magnetic nanomaterials for regenerative medicine applications include the incorporation of magnetic biomaterials within 3D scaffolds resulting in mechanoresponsive systems with unprecedented properties and the use of nanomagnetic actuators to control cell signaling. Mechano-responsive scaffolds and nanomagnetic systems can act as mechanostimulation platforms to apply forces directly to single cells and multicellular biological tissues. As transmitters of forces in a localized manner, the approaches enable the downstream activation of key tenogenic signaling pathways. In this minireview, we provide a brief outlook on the tenogenic signaling pathways which are most associated with the conversion of mechanical input into biochemical signals, the novel bio-magnetic approaches which can activate these pathways, and the efforts to translate magnetic biomaterials into regenerative platforms for tendon repair.

中文翻译：

磁性生物材料和纳米指导工具作为肌腱机械转导的介质

肌腱组织将肌肉与骨骼连接起来，允许传递力从而导致关节运动。肌腱损伤在社会上普遍存在，对公众健康的影响备受关注。因此，需要肌腱治疗的临床选择，而组织工程旨在提供可靠且成功的长期再生解决方案。此外，通过触发细胞内途径来调节细胞命运的可能性是再生医学当前的挑战。在过去的十年中，磁性纳米颗粒作为纳米指导工具的使用导致了诊断和治疗方面的巨大进步。将磁性纳米材料用于再生医学应用的最新进展包括将磁性生物材料纳入 3D 支架中，从而产生具有前所未有的特性的机械响应系统，以及使用纳米磁性执行器来控制细胞信号传导。机械响应支架和纳米磁性系统可以作为机械刺激平台，直接向单细胞和多细胞生物组织施加力。作为局部力的传递者，这些方法能够下游激活关键的肌腱信号通路。在这篇小综述中，我们对与机械输入转化为生化信号最相关的肌腱信号通路、可以激活这些通路的新型生物磁方法以及将磁性生物材料转化为再生平台的努力进行了简要展望用于肌腱修复。

更新日期：2020-02-13

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文