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Dynamically tunable elasto-inertial particle focusing and sorting in microfluidics.
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-01-02 , DOI: 10.1039/c9lc01071h Yinning Zhou 1 , Zhichao Ma 1 , Ye Ai 1
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-01-02 , DOI: 10.1039/c9lc01071h Yinning Zhou 1 , Zhichao Ma 1 , Ye Ai 1
Affiliation
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Inertial particle separation using passive hydrodynamic forces has attracted great attention in the microfluidics community because of its operation simplicity and high throughput sample processing. Due to the passive nature of inertial microfluidics, each inertial sorting device is typically fixed to a certain cut-off size for particle separation that is mainly dependent on the channel geometry and dimensions, which however lacks tunability in the separation threshold to fulfill the needs of different sorting applications. In this work, we explore the use of non-Newtonian viscoelastic fluids to achieve size-tunable elasto-inertial particle focusing and sorting in a microfluidic device with reverse wavy channel structures. The balance and competition among inertial lift force, Dean drag force and the controllable elastic lift force give rise to interesting size-based particle focusing phenomena with tunability in the equilibrium focusing positions. Seven differently sized fluorescent microspheres (0.3, 2, 3, 5, 7, 10 and 15 μm) are used to investigate the effects of the flow rate, viscoelastic fluid concentration and particle size on the tunable elasto-inertial focusing behavior. With the sorting tunability, we have achieved a highly effective sorting of a particle mixture into three subpopulations based on the particle size, i.e., small, intermediate and large subpopulations. We even demonstrate the controllable tunability among three separation thresholds for elasto-inertial particle sorting without changing the geometry and dimensions of the microfluidic device. The tunability of the developed elasto-inertial particle focusing and sorting can significantly broaden its application in a variety of biomedical research studies.
中文翻译：
微流体中的动态可调弹性惯性粒子聚焦和分选。
利用被动流体动力进行惯性颗粒分离，由于其操作简便和高通量样品处理，在微流体领域引起了极大的关注。由于惯性微流体的被动性质，每个惯性分选设备通常固定到某个特定的颗粒分离临界值，该临界值主要取决于通道的几何形状和尺寸，但是分离阈值缺乏可调节性，无法满足分离的需要。不同的分类应用程序。在这项工作中，我们探索使用非牛顿粘弹性流体在具有反向波浪通道结构的微流体装置中实现尺寸可调的弹性惯性粒子聚焦和分选。惯性提升力之间的平衡与竞争 迪安拖曳力和可控制的弹性升力产生了有趣的基于尺寸的粒子聚焦现象，并且在平衡聚焦位置具有可调性。七个不同尺寸的荧光微球（0.3、2、3、5、7、10和15μm）用于研究流速，粘弹性流体浓度和粒径对可调弹性惯性聚焦行为的影响。通过分选可调性，我们已经基于颗粒大小（即小，中和大子群）将颗粒混合物高效地分选为三个子群。我们甚至展示了用于弹性惯性粒子分选的三个分离阈值之间可控的可调性，而没有改变微流体装置的几何形状和尺寸。
更新日期：2020-02-13
中文翻译：
微流体中的动态可调弹性惯性粒子聚焦和分选。
利用被动流体动力进行惯性颗粒分离，由于其操作简便和高通量样品处理，在微流体领域引起了极大的关注。由于惯性微流体的被动性质，每个惯性分选设备通常固定到某个特定的颗粒分离临界值，该临界值主要取决于通道的几何形状和尺寸，但是分离阈值缺乏可调节性，无法满足分离的需要。不同的分类应用程序。在这项工作中，我们探索使用非牛顿粘弹性流体在具有反向波浪通道结构的微流体装置中实现尺寸可调的弹性惯性粒子聚焦和分选。惯性提升力之间的平衡与竞争 迪安拖曳力和可控制的弹性升力产生了有趣的基于尺寸的粒子聚焦现象，并且在平衡聚焦位置具有可调性。七个不同尺寸的荧光微球（0.3、2、3、5、7、10和15μm）用于研究流速，粘弹性流体浓度和粒径对可调弹性惯性聚焦行为的影响。通过分选可调性，我们已经基于颗粒大小（即小，中和大子群）将颗粒混合物高效地分选为三个子群。我们甚至展示了用于弹性惯性粒子分选的三个分离阈值之间可控的可调性，而没有改变微流体装置的几何形状和尺寸。
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