Vitamin D deficiency (VDD) is one of the serious and highly debatable public health problems affecting at least one billion of world population. This study objected to evaluate Vitamin D status in adult population of both sexes residing in different geographical areas of Kazakhstan and to elucidate the possible contributing factors related to VDD. This cross-sectional study covered 6 regions of Kazakhstan and applied the systematic random sampling to recruit 1347 healthy adults (of whom 819 were females) with mean age 44 ± 14 years. The concentration of 25-hydroxy vitamin D (25-OHD) was measured from May 2018 to August 2018 with Architect 25OH Vitamin D assay (Abbott Ireland Diagnostics Division Lisnamuck, Longford Co. Longford Ireland). Vitamin D deficiency was defined as 25-OHD values not exceeding 20 ng/mL as a reference threshold in healthy population. The median serum 25(OH)D concentrations in all studied regions of Kazakhstan were below the reference threshold (20 ng/mL). The lowest range of vitamin D (<10 ng/mL) was observed more commonly in females (34.6 % - 283) as compared to males (16.7 % - 88) and was significantly higher in Asians (33.2 % - 352) in contrast with Caucasians (6.7 % - 19) (χ2 = 177,939; D.f. = 3; p-value=<0,001). The proportion of severe VDD was higher in individuals with low body mass index (31.1 % - 188) vs. individuals with high body mass index (18.7 % - 50). In this study individuals aged 60 years and older had the most favorable situation with 25-OHD concentrations since these were normal in 14.4 % of observations (χ2 = 26,589; D.f. = 6; p-value=<0001). Studying the prevalence of VDD is an important public health task. Further research is needed to understand the epidemiology of VDD in more details to tailor intervention programs.

中文翻译：

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哈萨克斯坦维生素D缺乏症：跨部门研究。

维生素D缺乏症（VDD）是严重的，值得商bat的公共卫生问题之一，影响了至少10亿的世界人口。这项研究的目的是评估居住在哈萨克斯坦不同地理区域的男女成年人口中维生素D的状况，并阐明可能与VDD相关的影响因素。这项横断面研究覆盖了哈萨克斯坦的6个地区，并应用系统随机抽样方法，招募了1347名平均年龄为44±14岁的健康成人（其中819位为女性）。从2018年5月至2018年8月，使用Architect 25OH维生素D测定法（Abbott Ireland Diagnostics Division Lisnamuck，Longford Co.Longford Ireland）测量了25-羟基维生素D（25-OHD）的浓度。维生素D缺乏症定义为健康人群中25-OHD值不超过20 ng / mL作为参考阈值。哈萨克斯坦所有研究区域的血清25（OH）D浓度中值均低于参考阈值（20 ng / mL）。与男性（16.7％-88）相比，女性（34.6％-283）维生素D最低范围（<10 ng / mL）更为常见，而与之相比，亚洲人（33.2％-352）则明显更高。高加索人（6.7％-19）（χ2= 177,939; Df = 3; p值= <0.001）。体重指数低的人（31.1％-188）的严重VDD比例高于体重指数高的人（18.7％-50）的比例。在这项研究中，年龄在60岁及以上的人使用25-OHD的浓度最有利，因为在14.4％的观察中这些浓度是正常的（χ2= 26,589； Df = 6；p值= <0001）。研究VDD的患病率是一项重要的公共卫生任务。需要进一步的研究来更详细地了解VDD的流行病学，以制定干预计划。