Abstract Environmental concerns and the depletion of fossil resources are the major factors that boost modern society towards bio-based and circular economy. To this end, the development of mathematical tools that can be used to perform rapid comparative analysis across multiple technology options is necessary. The aim of this work is to present a simple and accurate mathematical model, which describes the economics of the bioreaction section of a typical biotransformation technology. The functional dependency of fixed capital investment (FCI) and utilities consumption from parameters determined experimentally is developed using a regression model. The proposed model, which consists only of three equations, can be used to compare the economic performance of different bio-based technologies that could potentially reach commercialization. More specifically, it can be used to estimate, at the early stages of process development, the effect of final broth concentration (titer), fermentation time and aeration rate on overall process economics.

中文翻译：

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用于计算大规模生物转化过程的固定资本投资和公用事业消耗的简单有效模型

摘要 环境问题和化石资源的枯竭是推动现代社会向生物基和循环经济发展的主要因素。为此，有必要开发可用于跨多种技术选项进行快速比较分析的数学工具。这项工作的目的是提出一个简单而准确的数学模型，它描述了典型生物转化技术的生物反应部分的经济性。固定资本投资 (FCI) 和公用事业消耗对实验确定参数的函数依赖性是使用回归模型开发的。所提出的模型仅由三个方程组成，可用于比较可能实现商业化的不同生物技术的经济表现。