Abstract In this study, the individual and simultaneous determination of lidocaine (LID) and epinephrine (EP) were examined using an anodically pretreated boron-doped diamond (APT-BDD) electrode. The results of cyclic voltammograms of the binary mixtures of EP and LID were manifested by two irreversible and diffusion-controlled peaks at about +0.91 V (for EP) and +1.67 V (for LID) in Britton-Robinson buffer at pH 2.0. The dependence of oxidation peak potential and current on experimental and instrumental parameters was also investigated at the surface of the APT-BDD electrode. Under the optimal conditions, employing square-wave voltammetric mode, the APT-BDD electrode was used for determination of LID and EP simultaneously in the ranges of 0.1–20.0 μmol L−1 and 1.0–100.0 μmol L−1, with detection limits of 0.03 μmol L−1 and 0.27 μmol L−1, respectively. The proposed approach could be used for their determination individually and selectively (in the case of EP) in pharmaceutical dosage forms with acceptable recoveries.

中文翻译：

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通过方波伏安法使用阳极预处理的掺硼金刚石电极对肾上腺素和利多卡因进行单独和同时电分析传感

摘要 在本研究中，使用阳极预处理的掺硼金刚石 (APT-BDD) 电极检查了利多卡因 (LID) 和肾上腺素 (EP) 的单独和同时测定。EP 和 LID 的二元混合物的循环伏安图结果表明，在 pH 2.0 的 Britton-Robinson 缓冲液中，在约 +0.91 V（对于 EP）和 +1.67 V（对于 LID）处的两个不可逆且扩散控制的峰表明。还在 APT-BDD 电极表面研究了氧化峰电位和电流对实验和仪器参数的依赖性。在最佳条件下，采用方波伏安模式，APT-BDD电极同时测定0.1-20.0 μmol L-1和1.0-100.0 μmol L-1范围内的LID和EP，检出限为0.03 μmol L-1 和 0.27 μmol L-1，分别。建议的方法可用于以可接受的回收率单独和选择性地（在 EP 的情况下）确定药物剂型中的它们。