Recent work has demonstrated that two archaic human groups (Neanderthals and Denisovans) interbred with modern humans and contributed to the contemporary human gene pool. These findings relied on the availability of high-coverage genomes from both Neanderthals and Denisovans. Here we search for evidence of archaic admixture from a worldwide panel of 1,667 individuals using an approach that does not require the presence of an archaic human reference genome. We find no evidence for archaic admixture in the Andaman Islands, as previously claimed, or on the island of Flores, where Homo floresiensis fossils have been found. However, we do find evidence for at least one archaic admixture event in sub-Saharan Africa, with the strongest signal in Khoesan and Pygmy individuals from Southern and Central Africa. The locations of these putative archaic admixture tracts are weighted against functional regions of the genome, consistent with the long-term effects of purifying selection against introgressed genetic material.

中文翻译：

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识别现代人和古人类之间的非洲特定混合物。

最近的工作表明，两个古老的人类群体（尼安德特人和丹尼索瓦人）与现代人类杂交，并为当代人类基因库做出了贡献。这些发现依赖于尼安德特人和丹尼索瓦人的高覆盖率基因组的可用性。在这里，我们使用一种不需要古人类参考基因组的方法，从一个由1,667名个体组成的全球专家小组中寻找古细菌混合物的证据。我们没有发现如先前所声称的在安达曼群岛或弗洛雷斯岛上发现过古混合物的证据，弗洛雷斯岛上发现了弗洛雷斯人化石。但是，我们确实找到了在撒哈拉以南非洲至少发生过一次古老混合事件的证据，在南部和中部非洲的Khoesan和Pygmy人中信号最强。