Memory T cells possess functional differences from naïve T cells that powerfully contribute to the efficiency of secondary immune responses. These abilities are imprinted during the primary response, linked to the acquisition of novel patterns of gene expression. Underlying this are alterations at the chromatin level (epigenetic modifications) that regulate constitutive and inducible gene transcription. T cell epigenetic memory can persist long-term, contributing to long-lasting immunity after infection or vaccination. However, acquired epigenetic states can also hinder effective tumor immunity or contribute to autoimmunity. The growing understanding of epigenetic gene regulation as it relates to both the stability and malleability of T cell memory may offer the potential to selectively modify T cell memory in disease by targeting epigenetic mechanisms.

中文翻译：

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T细胞记忆的表观遗传学调控：回顾治疗意义。

记忆T细胞与幼稚T细胞具有功能差异，这些功能极大地促进了次级免疫反应的效率。这些能力是在主要反应过程中被印记的，与获得新的基因表达模式有关。这是在染色质水平上的改变（表观遗传修饰），其调节组成型和诱导型基因转录。T细胞表观遗传记忆可以长期持续，有助于感染或接种疫苗后产生持久的免疫力。但是，获得性表观遗传状态也可能阻碍有效的肿瘤免疫或促进自身免疫。