Altered lipid metabolism is among the most prominent metabolic alterations in cancer. Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor formation. Lipids are a highly complex group of biomolecules that not only constitute the structural basis of biological membranes but also function as signaling molecules and an energy source. Here, we summarize recent evidence implicating altered lipid metabolism in different aspects of the cancer phenotype and discuss potential strategies by which targeting lipid metabolism could provide a therapeutic window for cancer treatment.

中文翻译：

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润滑癌症机器的轮子：脂质代谢在癌症中的作用。

脂质代谢改变是癌症中最突出的代谢改变之一。脂质合成或摄取的增强有助于癌细胞的快速生长和肿瘤的形成。脂质是一组高度复杂的生物分子，不仅构成生物膜的结构基础，而且还充当信号分子和能源的功能。在这里，我们总结了在癌症表型的不同方面牵涉到脂质代谢改变的最新证据，并讨论了靶向脂质代谢为癌症治疗提供治疗窗口的潜在策略。