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Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome.
Cell Metabolism ( IF 27.7 ) Pub Date : 2019-12-05 , DOI: 10.1016/j.cmet.2019.11.004
Michael J Wilkinson 1 , Emily N C Manoogian 2 , Adena Zadourian 1 , Hannah Lo 1 , Savannah Fakhouri 2 , Azarin Shoghi 2 , Xinran Wang 2 , Jason G Fleischer 2 , Saket Navlakha 2 , Satchidananda Panda 2 , Pam R Taub 1
Affiliation  

In animal models, time-restricted feeding (TRF) can prevent and reverse aspects of metabolic diseases. Time-restricted eating (TRE) in human pilot studies reduces the risks of metabolic diseases in otherwise healthy individuals. However, patients with diagnosed metabolic syndrome often undergo pharmacotherapy, and it has never been tested whether TRE can act synergistically with pharmacotherapy in animal models or humans. In a single-arm, paired-sample trial, 19 participants with metabolic syndrome and a baseline mean daily eating window of ≥14 h, the majority of whom were on a statin and/or antihypertensive therapy, underwent 10 h of TRE (all dietary intake within a consistent self-selected 10 h window) for 12 weeks. We found this TRE intervention improves cardiometabolic health for patients with metabolic syndrome receiving standard medical care including high rates of statin and anti-hypertensive use. TRE is a potentially powerful lifestyle intervention that can be added to standard medical practice to treat metabolic syndrome. VIDEO ABSTRACT.

中文翻译:

限时十小时饮食可减少代谢综合征患者的体重,血压和致动脉血脂。

在动物模型中,限时喂养(TRF)可以预防和逆转新陈代谢疾病。在人类先导研究中,限时饮食(TRE)降低了其他健康人群的代谢性疾病风险。然而,诊断为代谢综合症的患者经常接受药物治疗,并且从未在动物模型或人类中测试过TRE是否可以与药物治疗协同作用。在单组配对样本试验中,有19名患有代谢综合症且基线平均每日进食窗≥14 h的参与者,其中大部分接受他汀和/或降压治疗,接受了10 h TRE(所有饮食)在一致的自我选择的10小时窗口内摄入),持续12周。我们发现这种TRE干预可改善接受标准医疗服务(包括高他汀类药物和抗高血压药物使用)的代谢综合征患者的心脏代谢健康。TRE是一种潜在有力的生活方式干预措施,可以添加到标准的医学实践中以治疗代谢综合征。视频摘要。
更新日期:2019-12-05
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