Chiral piperidines represent the most common heterocycles in small-molecule medicines. In this issue of Chem, Nagib and co-workers describe the development of an enantioselective remote cyanation of amines via copper-catalyzed radical relay. This represents a unique example of asymmetric interrupted Hofmann-Löffler reactivity and leads to the straightforward assembly of chiral piperidines.

中文翻译：

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铜可中断N自由基反应并能获得对映纯的哌啶

手性哌啶代表小分子药物中最常见的杂环。在Chem的这一期中，Nagib及其同事描述了通过铜催化的自由基中继作用发展胺的对映选择性远程氰化反应的方法。这代表了不对称中断的霍夫曼-洛夫勒反应性的独特例子，并导致了手性哌啶的直接组装。