Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections.,Advanced Science

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Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections.
Advanced Science ( IF 14.3 ) Pub Date : 2019-12-05 , DOI: 10.1002/advs.201901872
Yu-Xuan Ma ₁ , Chen-Yu Wang ₁ , Yuan-Yuan Li ₁ , Jing Li ₁ , Qian-Qian Wan ₁ , Ji-Hua Chen ₁ , Franklin R Tay _{1,

2} , Li-Na Niu _{1,

2}

Affiliation

ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are among the most common opportunistic pathogens in nosocomial infections. ESKAPE pathogens distinguish themselves from normal ones by developing a high level of antibiotic resistance that involves multiple mechanisms. Contemporary therapeutic strategies which are potential options in combating ESKAPE bacteria need further investigation. Herein, a broad overview of the antimicrobial research on ESKAPE pathogens over the past five years is provided with prospective clinical applications.

中文翻译：

对抗 ESKAPE 病原体对抗医院感染的注意事项和注意事项。

ESKAPE 病原体（屎肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属）是医院感染中最常见的机会性病原体。ESKAPE 病原体通过产生涉及多种机制的高水平抗生素耐药性来区别于正常病原体。现代治疗策略是对抗 ESKAPE 细菌的潜在选择，需要进一步研究。本文对过去五年 ESKAPE 病原体的抗菌研究进行了广泛的概述，并提出了前瞻性的临床应用。

更新日期：2019-12-05

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