The nucleolus is a phase-separated cell condensate where the initial steps of ribosome biogenesis take place. In this issue of Molecular Cell, Yao et al. (2019) report a super-resolution microscopy analysis of the internal structure of the nucleolus, revealing how nascent precursor ribosomal RNAs are initially partitioned and processed in this multilayered biocondensate.

中文翻译：

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核仁隔室的诞生：相分离驱动的核糖体RNA分选和加工。

核仁是相分离的细胞凝缩物，核糖体生物发生的初始步骤在此发生。在本期《分子细胞》中，Yao等人。（2019）报告了核仁内部结构的超高分辨率显微镜分析，揭示了新生的前体核糖体RNA是如何在这种多层生物冷凝物中初步分配和加工的。