We established three types of thrombosis models to explore the effects of the static magnetic field (SMF) on thrombosis in rats and mice with three different MF intensities. In the carrageenan-induced thrombosis model in rats, the SMF treatments reduced the black tail length of rats, extracorporeal thrombus, and the mass of wet and dry thrombus, and improved the coagulation index value. In FeCl3 -induced arterial thrombosis model in rats, the SMF treatment showed some anti-thrombotic effects. More specifically, the SMF treatment affected rodent blood pressure, plasma plasminogen activator inhibitor, tissue-type plasminogen activator, thrombus mass, and thrombus protein content. In the adrenaline-induced thrombosis model in mice, the SMF treatment had certain effects on the diameter and blood flow velocity of mouse auricle microcirculation in fine veins and arteries. Overall, the highest MF intensities we tested, 20-150 mT, showed a trend of anti-thrombotic effect, indicating that the moderate-intensity SMF might serve as a potential treatment for clot-related diseases in the future. Bioelectromagnetics. 2020;41:52-62 © 2019 Bioelectromagnetics Society.

中文翻译：

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中等强度的静磁场可防止大鼠和小鼠的血栓形成。

我们建立了三种类型的血栓形成模型，以探讨静磁场（SMF）对具有三种不同MF强度的大鼠和小鼠血栓形成的影响。在角叉菜胶诱发的大鼠血栓形成模型中，SMF处理可减少大鼠的黑尾长度，体外血栓以及干，湿血栓的质量，并改善凝血指标值。在FeCl3诱导的大鼠动脉血栓形成模型中，SMF处理显示出一定的抗血栓形成作用。更具体地说，SMF处理会影响啮齿动物的血压，血浆纤溶酶原激活物抑制剂，组织型纤溶酶原激活物，血栓质量和血栓蛋白含量。在肾上腺素诱发的小鼠血栓形成模型中，SMF处理对小鼠小静脉微动脉的微循环的直径和血流速度有一定的影响。总体而言，我们测试的最高MF强度为20-150 mT，显示出抗血栓形成作用的趋势，这表明中等强度的SMF可能在将来成为治疗血栓相关疾病的潜在方法。生物电磁学。2020; 41：52-62©2019生物电磁学会。