The Synthesis of a 2D Ultra-Large Protein Supramolecular Nanofilm by Chemoselective Thiol-Disulfide Exchange and its Emergent Functions.,Angewandte Chemie International Edition

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The Synthesis of a 2D Ultra-Large Protein Supramolecular Nanofilm by Chemoselective Thiol-Disulfide Exchange and its Emergent Functions.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2019-12-04 , DOI: 10.1002/anie.201912848
Yan Xu ₁ , Yongchun Liu ₁ , Xinyi Hu ₁ , Rongrong Qin ₁ , Hao Su ₁ , Juling Li ₁ , Peng Yang ₁

Affiliation

The design and scalable synthesis of robust 2D biological ultrathin films with a tunable structure and function and the ability to be easily transferred to a range of substrates remain key challenges in chemistry and materials science. Herein, we report the use of the thiol-disulfide exchange reaction in the synthesis of a macroscopic 2D ultrathin proteinaceous film with the potential for large-scale fabrication and on-demand encapsulation/release of functional molecules. The reaction between the Cys6-Cys127 disulfide bond of lysozyme and cysteine is chemo- and site-selective. The partially unfolded lysozyme-cysteine monomers aggregate at the air/water or solid/liquid interface to form an ultra-large 2D nanofilm (900 cm2 ) with about 100 % optical transparency. This material adheres to a wide range of substrates and encapsulates and releases a range of molecules without significantly affecting activity.

中文翻译：

化学选择性巯基-二硫键交换合成二维超大蛋白超分子纳米膜及其新功能。

具有可调整的结构和功能以及能够轻松转移到多种基材的能力的稳健2D生物超薄膜的设计和可扩展合成，仍然是化学和材料科学领域的关键挑战。在本文中，我们报道了巯基-二硫键交换反应在宏观2D超薄蛋白质膜合成中的应用，具有大规模制造和按需封装/释放功能分子的潜力。溶菌酶的Cys6-Cys127二硫键与半胱氨酸之间的反应是化学和位点选择性的。部分展开的溶菌酶-半胱氨酸单体在空气/水或固体/液体界面聚集，形成具有约100％光学透明性的超大二维纳米膜（900平方厘米）。

更新日期：2020-01-16

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