Abstract The peculiarities of the adsorption of the anticancer drug, 5-fluorouracil, by aluminosilicate matrices with different morphologies — BEA zeolites, layered silicates with saponite (Mg3Si4O10(OH)2.H2O) and montmorillonite (Na0.2Al1.8Mg0.2Si4O10(OH)2.H2O) structures, and nanotubular halloysites (Al2Si2O5(OH)4.2H2O) were investigated. The influence of the polarity of the solvent used (water, acetone, and ethanol), pH-environment (pH = 5, 8, and 11), morphology (framed, layered, and nanotubular), and chemical composition (Al2O3 content 0–40 wt%) of the initial matrix on the amount of the adsorbed drug was studied. To prevent errors associated with the possibility of the existence of various tautomeric forms of fluorouracil in solutions, the adsorption processes were exclusively analysed using thermal analysis coupled with mass spectrometry. The efficiency of 5-fluorouracil adsorption and the loading conditions are largely determined by the chemical composition of the initial aluminosilicate matrix and its morphology. Zeolite exhibited the highest adsorption capacity for fluorouracil under any saturation conditions, while the halloysite matrix showed the lowest capacity.

中文翻译：

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5-氟尿嘧啶在不同形貌多孔硅铝酸盐上的吸附特性

摘要 抗癌药物 5-氟尿嘧啶被不同形态的铝硅酸盐基质吸附的特性——BEA 沸石、层状硅酸盐与皂石 (Mg3Si4O10(OH)2.H2O) 和蒙脱石 (Na0.2Al1.8Mg0.2Si4O10(OH) )2.H2O) 结构和纳米管状埃洛石 (Al2Si2O5(OH)4.2H2O) 进行了研究。所用溶剂的极性（水、丙酮和乙醇）、pH 环境（pH = 5、8 和 11）、形态（框架、层状和纳米管）和化学成分（Al2O3 含量 0–研究了初始基质的 40 wt% 对吸附药物量的影响。为了防止与溶液中存在各种互变异构形式的氟尿嘧啶的可能性相关的错误，吸附过程专门使用热分析与质谱联用进行分析。5-氟尿嘧啶的吸附效率和加载条件在很大程度上取决于初始硅铝酸盐基质的化学成分及其形态。在任何饱和条件下，沸石对氟尿嘧啶的吸附能力最高，而埃洛石基体的吸附能力最低。