当前位置: X-MOL 学术Nat. Rev. Cancer › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Brain immunology and immunotherapy in brain tumours.
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2019-12-05 , DOI: 10.1038/s41568-019-0224-7
John H Sampson 1, 2 , Michael D Gunn 3 , Peter E Fecci 1, 2, 4 , David M Ashley 1
Affiliation  

Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet, seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of the immune system within the central nervous system (CNS) and altered the paradigm for successful immunotherapy. The impact of standard therapies on the response to immunotherapy is now better understood, as well. This new knowledge has implications for a broad range of tumours that develop within the CNS. Nevertheless, the requirements for successful therapy remain effective delivery and target specificity, while the dramatic heterogeneity of malignant gliomas at the genetic and immunological levels remains a profound challenge.

中文翻译:

脑免疫学和脑肿瘤的免疫治疗。

神经胶质瘤是最常见的恶性原发性脑肿瘤,仍然普遍致命。然而,过去 5 年的开创性发现阐明了中枢神经系统 (CNS) 内免疫系统的解剖结构、遗传学和功能,并改变了成功免疫治疗的范例。标准疗法对免疫疗法反应的影响现在也得到了更好的理解。这一新知识对中枢神经系统内发生的多种肿瘤具有重要意义。然而,成功治疗的要求仍然是有效的递送和靶标特异性,而恶性神经胶质瘤在遗传和免疫学水平上的显着异质性仍然是一个严峻的挑战。
更新日期:2019-12-05
down
wechat
bug