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On macrophage diversity and inflammatory metabolic timers.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2020-02-01 , DOI: 10.1038/s41577-019-0260-2 Peter J Murray 1
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2020-02-01 , DOI: 10.1038/s41577-019-0260-2 Peter J Murray 1
Affiliation
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Key papers were published in 2019 that solidify the notion that macrophage gene expression is remarkably diverse; single-cell sequencing combined with new macrophage-specific genetic tools has provided unexpected insights into the tissue-specific and inflammatory diversity of macrophages. In addition, a new mechanism of inflammatory control of macrophage diversity based on lactate-mediated histone modifications was discovered. In 2019, single-cell sequencing studies provided important insight into the diverse gene expression profiles of tissue macrophages, and new systems for specifically deleting macrophages were reported. A lactate ‘timer’ that controls inflammatory responses in macrophages was also described.
中文翻译：
关于巨噬细胞的多样性和炎性代谢定时器。
2019年发表了关键论文，巩固了巨噬细胞基因表达差异显着的观点; 单细胞测序与新的巨噬细胞特异性遗传工具相结合，为巨噬细胞的组织特异性和炎症多样性提供了意想不到的见识。另外，发现了基于乳酸介导的组蛋白修饰的炎症控制巨噬细胞多样性的新机制。在2019年，单细胞测序研究为组织巨噬细胞的多种基因表达谱提供了重要的见识，并报道了专门删除巨噬细胞的新系统。还描述了控制巨噬细胞炎症反应的乳酸“计时器”。
更新日期：2019-12-05
中文翻译：
关于巨噬细胞的多样性和炎性代谢定时器。
2019年发表了关键论文，巩固了巨噬细胞基因表达差异显着的观点; 单细胞测序与新的巨噬细胞特异性遗传工具相结合，为巨噬细胞的组织特异性和炎症多样性提供了意想不到的见识。另外，发现了基于乳酸介导的组蛋白修饰的炎症控制巨噬细胞多样性的新机制。在2019年，单细胞测序研究为组织巨噬细胞的多种基因表达谱提供了重要的见识，并报道了专门删除巨噬细胞的新系统。还描述了控制巨噬细胞炎症反应的乳酸“计时器”。
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