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NCX activity generates spontaneous Ca2+ oscillations in the astrocytic leaflet microdomain.
Cell Calcium ( IF 4.3 ) Pub Date : 2019-12-05 , DOI: 10.1016/j.ceca.2019.102137 László Héja 1 , Julianna Kardos 1
Cell Calcium ( IF 4.3 ) Pub Date : 2019-12-05 , DOI: 10.1016/j.ceca.2019.102137 László Héja 1 , Julianna Kardos 1
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The synergy between synaptic Glu release and astrocytic Glu-Na+ symport is essential to the signalling function of the tripartite synapse. Here we used kinetic data of astrocytic Glu transporters (EAAT) and the Na+/Ca2+ exchanger (NCX) to simulate Glu release, Glu uptake and subsequent Na+ and Ca2+ dynamics in the astrocytic leaflet microdomain following single release event. Model simulations show that Glu-Na+ symport differently affect intracellular [Na+] in synapses with different extent of astrocytic coverage. Surprisingly, NCX activity alone has been shown to generate markedly stable, spontaneous Ca2+ oscillation in the astrocytic leaflet. These on-going oscillations appear when NCX operates either in the forward or reverse direction. We conjecture that intrinsic NCX activity may play a prominent role in the generation of astrocytic Ca2+ oscillations.
中文翻译：
NCX活性在星形细胞小叶微区中自发产生Ca2 +振荡。
突触的Glu释放与星形胶质细胞的Glu-Na +交汇之间的协同作用对于三方突触的信号传导功能至关重要。在这里，我们使用星形细胞的Glu转运蛋白（EAAT）和Na + / Ca2 +交换剂（NCX）的动力学数据来模拟单个释放事件后星形细胞小叶微区中的Glu释放，Glu吸收以及随后的Na +和Ca2 +动态。模型仿真表明，Glu-Na +的同向运动在不同程度的星形胶质细胞覆盖的突触中对细胞内[Na +]的影响不同。令人惊讶的是，仅NCX活性已显示在星形细胞小叶中产生明显稳定的自发Ca2 +振荡。当NCX正向或反向操作时，会出现这些持续的振荡。
更新日期：2019-12-05
中文翻译：
NCX活性在星形细胞小叶微区中自发产生Ca2 +振荡。
突触的Glu释放与星形胶质细胞的Glu-Na +交汇之间的协同作用对于三方突触的信号传导功能至关重要。在这里，我们使用星形细胞的Glu转运蛋白（EAAT）和Na + / Ca2 +交换剂（NCX）的动力学数据来模拟单个释放事件后星形细胞小叶微区中的Glu释放，Glu吸收以及随后的Na +和Ca2 +动态。模型仿真表明，Glu-Na +的同向运动在不同程度的星形胶质细胞覆盖的突触中对细胞内[Na +]的影响不同。令人惊讶的是，仅NCX活性已显示在星形细胞小叶中产生明显稳定的自发Ca2 +振荡。当NCX正向或反向操作时，会出现这些持续的振荡。
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