A once-a-month oral contraceptive.,Science Translational Medicine

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A once-a-month oral contraceptive.
Science Translational Medicine ( IF 15.8 ) Pub Date : 2019-12-04 , DOI: 10.1126/scitranslmed.aay2602
Ameya R Kirtane _{1,

2} , Tiffany Hua _{1,

2} , Alison Hayward _{1,

2,

3} , Ambika Bajpayee ₄ , Aniket Wahane _{1,

2} , Aaron Lopes _{1,

2} , Taylor Bensel _{1,

2} , Lihong Ma ₅ , Frank Z Stanczyk ₅ , Sierra Brooks ₁ , Declan Gwynne _{1,

2} , Jacob Wainer _{1,

2} , Joy Collins _{1,

2} , Siddartha M Tamang _{1,

2} , Robert Langer _{1,

2,

6,

7,

8} , Giovanni Traverso _{8,

9}

Affiliation

Poor patient adherence to oral contraceptives is the predominant cause of failure of these therapies, leading to unplanned pregnancies that can negatively affect female health worldwide. To improve patient adherence, we developed an oral contraceptive that is administered once a month. Here, we describe the design and report in vivo characterization of a levonorgestrel-releasing gastric resident dosage form in pigs.

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