A New Chemometric Strategy in Electrochemical Method Optimization for the Quantification of Cefdinir in Tablets, Effervescent Tablets and Suspension Samples,Electroanalysis

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A New Chemometric Strategy in Electrochemical Method Optimization for the Quantification of Cefdinir in Tablets, Effervescent Tablets and Suspension Samples
Electroanalysis ( IF 2.7 ) Pub Date : 2019-12-05 , DOI: 10.1002/elan.201900574
Erdal Dinç ₁ , Saadet Dermiş ₁ , Seda Can Akcasoy ₁ , Zehra Ceren Ertekin ₁

Affiliation

A new voltammetric method, based on the use of single‐use pencil graphite electrode, was developed for the quantitative determination of cefdinir by square wave voltammetry. Chemometric optimization strategy was used to select the suitable values for three experimental parameters (pH of the supporting electrolyte, frequency and square wave amplitude) by applying a 3³ full factorial design model. The optimal voltammetric conditions were found to be pH 5.0 for supporting electrolyte (Britton‐Robinson buffer), 43 mV for square wave amplitude and 108 Hz for frequency. Square wave voltammograms of calibration, validation and unknown samples were recorded between 0.0–1400 mV under the optimized voltammetric conditions. Linear regression equation was computed in the linear working range of 0.5–20 μg/mL by using the relationship between the concentration and peak current at 600 mV. The optimized voltammetric method was validated by assessing the analysis results of validation samples. Then the proposed method was applied for the quantitative determination of cefdinir in three different pharmaceutical preparations, namely film‐coated tablets, effervescent tablets and powder for oral suspension. It was concluded that the proposed voltammetric method was suitable for the quantitative analysis of commercial pharmaceutical preparations containing cefdinir.

中文翻译：

电化学方法优化中新的化学计量学策略，用于定量测定片剂，泡腾片和悬浮液中头孢地尼的含量

开发了一种基于一次性铅笔石墨电极的伏安法，用于通过方波伏安法定量测定头孢地尼。使用化学计量优化策略，通过应用3 ³来选择三个实验参数（支持电解质的pH，频率和方波幅度）的合适值。完整的析因设计模型。发现最佳的伏安条件是支持电解质的pH值为5.0（Britton-Robinson缓冲液），方波幅度为43 mV，频率为108 Hz。在最佳伏安条件下，在0.0-1400 mV之间记录了校准，验证和未知样品的方波伏安图。利用浓度与600 mV峰值电流之间的关系，在0.5-20μg/ mL的线性工作范围内计算出线性回归方程。通过评估验证样品的分析结果对优化的伏安法进行了验证。然后，将所建议的方法用于三种不同药物制剂中头孢地尼的定量测定，分别是薄膜衣片，泡腾片和口服混悬剂粉剂。

更新日期：2019-12-05

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