BACKGROUND Data mining of The Cancer Genome Atlas (TCGA) data has significantly facilitated cancer genome research and provided unprecedented opportunities for cancer researchers. However, existing web applications for DNA methylation analysis does not adequately address the need of experimental biologists, and many additional functions are often required. RESULTS To facilitate DNA methylation analysis, we present the SMART (Shiny Methylation Analysis Resource Tool) App, a user-friendly and easy-to-use web application for comprehensively analyzing the DNA methylation data of TCGA project. The SMART App integrates multi-omics and clinical data with DNA methylation and provides key interactive and customized functions including CpG visualization, pan-cancer methylation profile, differential methylation analysis, correlation analysis and survival analysis for users to analyze the DNA methylation in diverse cancer types in a multi-dimensional manner. CONCLUSION The SMART App serves as a new approach for users, especially wet-bench scientists with no programming background, to analyze the scientific big data and facilitate data mining. The SMART App is available at http://www.bioinfo-zs.com/smartapp.

中文翻译：

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SMART应用程序：用于全面DNA甲基化分析和可视化的交互式Web应用程序。

背景技术癌症基因组图谱（TCGA）数据的数据挖掘显着促进了癌症基因组研究，并为癌症研究人员提供了前所未有的机会。但是，现有的用于DNA甲基化分析的Web应用程序无法充分满足实验生物学家的需求，并且经常需要许多其他功能。结果为了促进DNA甲基化分析，我们提出了SMART（发光甲基化分析资源工具）应用程序，这是一个用户友好且易于使用的Web应用程序，用于全面分析TCGA项目的DNA甲基化数据。SMART App将多组学和临床数据与DNA甲基化整合在一起，并提供关键的交互式和自定义功能，包括CpG可视化，全癌甲基化概况，差异甲基化分析，相关性分析和生存分析，以便用户以多维方式分析各种癌症类型中的DNA甲基化。结论SMART App为用户（尤其是没有编程背景的湿床科学家）提供了一种分析科学大数据并促进数据挖掘的新方法。可在http://www.bioinfo-zs.com/smartapp上获取SMART App。