BACKGROUND Omentin and adiponectin are among the anti-inflammatory and anti-atherogenic adipokines that have potentially beneficial effects on cardiovascular disorders. Recent studies indicate a paradoxical relationship between adiponectin and cardiovascular mortality across many clinical settings including type 2 diabetes. In this study, we characterized the clinical features of type 2 diabetes patients with increased adiponectin levels and examined the association between omentin and atherosclerosis in those patients. METHODS The subjects were 413 patients with type 2 diabetes. Fasting plasma omentin and total adiponectin levels were measured by enzyme-linked immunosorbent assay. The intima-media thickness (IMT) of the common carotid artery was measured by ultrasonography. The subjects were stratified according to the median value of plasma adiponectin. RESULTS In high-adiponectin group, omentin levels were higher, while IMT tended to be greater than those in low-adiponectin group. The high-adiponectin group also exhibited older age, higher systolic blood pressure, lower kidney function, body mass index, and insulin resistance index compared to the low-adiponectin group. Multivariate analysis revealed that omentin levels were independently and negatively associated with IMT in high-adiponectin group, but not in low-adiponectin group, after adjusting for adiponectin levels and traditional cardiovascular risk factors. On the other hand, adiponectin levels were not significantly associated with IMT in either group. CONCLUSIONS Plasma omentin levels are inversely associated with IMT in type 2 diabetes patients with increased adiponectin levels and multiple cardiovascular risk factors. This study suggests a protective role of omentin against atherosclerosis in type 2 diabetes patients, which is potentially influenced by adiponectin level and cardiovascular risk status.

中文翻译：

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横断面研究显示，血浆omentin水平与血浆脂联素水平升高的2型糖尿病患者的动脉粥样硬化成反比。

背景技术网膜蛋白和脂联素是抗发炎和抗动脉粥样硬化的脂肪因子之一，对心血管疾病具有潜在的有益作用。最近的研究表明，在包括2型糖尿病在内的许多临床环境中，脂联素与心血管死亡率之间存在自相矛盾的关系。在这项研究中，我们表征了脂联素水平升高的2型糖尿病患者的临床特征，并检查了网膜蛋白与这些患者中动脉粥样硬化之间的关联。方法研究对象为413例2型糖尿病患者。空腹血浆omentin和总脂联素水平通过酶联免疫吸附法测定。通过超声测量颈总动脉的内膜中层厚度（IMT）。根据血浆脂联素的中位数对受试者进行分层。结果在高脂联素组中，网膜蛋白水平较高，而IMT则高于低脂联素组。与低脂联素组相比，高脂联素组还表现出年龄更大，收缩压更高，肾功能，体重指数和胰岛素抵抗指数更低。多因素分析显示，在调整了脂联素水平和传统的心血管危险因素后，高脂联素组中网膜蛋白水平与IMT呈独立负相关，而低脂联素组则与IMT无关。另一方面，两组脂联素水平与IMT均无显着相关。结论在脂联素水平升高和多种心血管危险因素的2型糖尿病患者中，血浆网膜蛋白水平与IMT呈负相关。这项研究表明，omentin在2型糖尿病患者中对动脉粥样硬化具有保护作用，这可能受脂联素水平和心血管风险状态的影响。