BACKGROUND Prostatic hyperplasia (PH) is one of the most important disorders in intact dogs. In this study, we aimed to induce PH experimentally using the combination of testosterone and estrogen and evaluate important factors associated with this disease. RESULTS The results showed that in the induction group, prostate volume and prostate specific antigen (PSA) concentration increased significantly on day 21 onwards compared to those of the control group. Canine prostatic specific esterase (CPSE) and dihydrotestosterone (DHT) concentrations increased significantly on day 42 onwards while the testosterone levels increased on day 63. In addition, prostatic acid phosphatase (PAP) concentration did not change significantly in the control and induction groups. Biochemistry profiles and hematologic factors were measured for monitoring the function of liver and kidney, and there were no adverse effects following the induction of PH. CONCLUSIONS It seems that testosterone and estrogen administration led to prostatic hyperplasia during 2 months. Investigating the size of the prostate, accompanied by prostate markers including CPSE, PSA, DHT, and testosterone, is helpful for the PH diagnosis. However, further studies should be carried out on PAP.

中文翻译：

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犬前列腺增生过程中特定血清生物标志物的变化。

背景技术前列腺增生（PH）是完整犬中最重要的疾病之一。在这项研究中，我们旨在通过睾丸激素和雌激素的组合通过实验诱导PH，并评估与该疾病相关的重要因素。结果结果表明，在诱导组中，与对照组相比，从第21天开始，前列腺体积和前列腺特异性抗原（PSA）浓度显着增加。犬的前列腺特异性酯酶（CPSE）和二氢睾丸激素（DHT）浓度在第42天开始显着增加，而睾丸激素水平在第63天增加。此外，对照组和诱导组的前列腺酸性磷酸酶（PAP）浓度没有显着变化。测量生化特征和血液学因素以监测肝和肾的功能，并且在诱发PH后没有副作用。结论似乎在2个月内服用睾丸激素和雌激素会导致前列腺增生。研究前列腺的大小，并伴以包括CPSE，PSA，DHT和睾丸激素在内的前列腺标志物，有助于PH的诊断。但是，应该对PAP进行进一步的研究。