当前位置：
X-MOL 学术
›
BMC Complement. Altern. Med.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum leaves and its effect on lung pathological changes in an ovalbumin-induced rat model of asthma.
BMC Complementary and Alternative Medicine ( IF 4.782 ) Pub Date : 2019-12-04 , DOI: 10.1186/s12906-019-2765-4 Naima Eftekhar 1 , Ali Moghimi 1 , Nema Mohammadian Roshan 2 , Saeideh Saadat 3 , Mohammad Hossein Boskabady 4, 5
BMC Complementary and Alternative Medicine ( IF 4.782 ) Pub Date : 2019-12-04 , DOI: 10.1186/s12906-019-2765-4 Naima Eftekhar 1 , Ali Moghimi 1 , Nema Mohammadian Roshan 2 , Saeideh Saadat 3 , Mohammad Hossein Boskabady 4, 5
Affiliation
BACKGROUND
Ocimum species (Lamiaceae) has been traditionally used for treatment of upper respiratory tract infections, bronchitis, coughs, sore throat, and wound healing. The Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum (O. basilicum) leaves was examined in ovalbumin sensitized animals.
METHODS
Wistar rats were divided to six groups; non-sensitized, sensitized to ovalbumin, sensitized and treated with dexamethasone (1.25 μg/mL), and O. basilicum extract (0.75, 1.50 and 3.00 mg/mL) in drinking water for 21 days. The levels of interleukin 4 (IL-4), interferon gamma (IFN-γ), IFN-γ/IL-4 ratio, immunoglobulin E (IgE), phospholipase A2 (PLA2) and total protein (TP) in BALF, and lung pathological changes were examined.
RESULTS
A significant increase in IL-4, IgE, PLA2 and TP levels, all lung pathological indices as well as significant decrease in IFN-γ/IL-4 ratio was seen in the asthmatic compared to the control rats (P < 0.05 to P < 0.001). Treatment with O. basilicum extract resulted in decreased IL-4, IgE, PLA2 and TP levels, but increased IFN-γ/IL-4 ratio compared to untreated sensitized rats (P < 0.01 to P < 0.001). The plant significantly improved the pathological changes of sensitized rats (P < 0.05 to P < 0.01). The improvement effects of higher concentrations of the O. basilicum extract were significantly more than those of dexamethasone (P < 0.05 to P < 0.001).
CONCLUSION
The improvement effects of O. basilicum on pathological changes, immunological and inflammatory markers in sensitized rats comparable or even more potent than dexamethasone suggests the therapeutic potential of the plant in asthma.
中文翻译：
罗勒叶的乙醇乙醇提取物的免疫调节和抗炎作用及其对卵白蛋白诱发的哮喘模型大鼠肺部病理变化的影响。
背景技术传统上，罗望子属（唇形科）用于治疗上呼吸道感染，支气管炎，咳嗽，喉咙痛和伤口愈合。在卵清蛋白致敏的动物中检查了罗勒叶的乙醇乙醇提取物的免疫调节和抗炎作用。方法Wistar大鼠分为六组。非敏化，对卵白蛋白敏化，在地塞米松（1.25μg/ mL）和紫苏提取物（0.75、1.50和3.00 mg / mL）中敏化并处理21天。BALF和肺中白介素4（IL-4），干扰素γ（IFN-γ），IFN-γ/ IL-4比率，免疫球蛋白E（IgE），磷脂酶A2（PLA2）和总蛋白（TP）的水平检查病理变化。结果IL-4，IgE，PLA2和TP水平显着增加，与对照组相比，哮喘组的所有肺部病理指标以及IFN-γ/ IL-4比率均显着下降（P <0.05至P <0.001）。与未经处理的致敏大鼠相比，用青蒿提取物处理可降低IL-4，IgE，PLA2和TP水平，但增加IFN-γ/ IL-4的比例（P <0.01至P <0.001）。该植物显着改善了致敏大鼠的病理变化（P <0.05至P <0.01）。较高浓度的O.basicum提取物对地塞米松的改善效果明显优于地塞米松（P <0.05至P <0.001）。结论罗勒果油对病理变化的改善作用，
更新日期：2019-12-04
中文翻译：
罗勒叶的乙醇乙醇提取物的免疫调节和抗炎作用及其对卵白蛋白诱发的哮喘模型大鼠肺部病理变化的影响。
背景技术传统上，罗望子属（唇形科）用于治疗上呼吸道感染，支气管炎，咳嗽，喉咙痛和伤口愈合。在卵清蛋白致敏的动物中检查了罗勒叶的乙醇乙醇提取物的免疫调节和抗炎作用。方法Wistar大鼠分为六组。非敏化，对卵白蛋白敏化，在地塞米松（1.25μg/ mL）和紫苏提取物（0.75、1.50和3.00 mg / mL）中敏化并处理21天。BALF和肺中白介素4（IL-4），干扰素γ（IFN-γ），IFN-γ/ IL-4比率，免疫球蛋白E（IgE），磷脂酶A2（PLA2）和总蛋白（TP）的水平检查病理变化。结果IL-4，IgE，PLA2和TP水平显着增加，与对照组相比，哮喘组的所有肺部病理指标以及IFN-γ/ IL-4比率均显着下降（P <0.05至P <0.001）。与未经处理的致敏大鼠相比，用青蒿提取物处理可降低IL-4，IgE，PLA2和TP水平，但增加IFN-γ/ IL-4的比例（P <0.01至P <0.001）。该植物显着改善了致敏大鼠的病理变化（P <0.05至P <0.01）。较高浓度的O.basicum提取物对地塞米松的改善效果明显优于地塞米松（P <0.05至P <0.001）。结论罗勒果油对病理变化的改善作用，
京公网安备 11010802027423号