BACKGROUND Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopaminergic neurons in substantia nigra pars compacta and clinically manifested mainly with motor dysfunctions. Plants are rich source of medicinally important bioactive compounds and inhabitants of underdeveloped countries used plants for treatment of various ailments. Albizia lebbeck has been reported to possess antioxidant and neuroprotective properties that suggest the evaluation of its traditional therapeutic potential in neurodegenerative diseases. The aim of present study was to validate the traditional use of Albizia lebbeck (L.) and delineate its mechanism of action in PD. The systems pharmacology approach was employed to explain the Albizia lebbeck (L.) mechanism of action in PD. METHODS The haloperidol-induced catalepsy was adopted as experimental model of PD for in-vivo studies in wistar albino rats. The systems pharmacology approach was employed to explain the Albizia lebbeck (L.) mechanism of action in PD. RESULTS In-vivo studies revealed that Albizia lebbeck improved the motor functions and endurance as demonstrated in behavioral studies which were further supported by the rescue of endogenous antioxidant defense and reversal of ultrastructural damages in histological studies. System pharmacology approach identified 25 drug like compounds interacting with 132 targets in a bipartite graph that revealed the synergistic mechanism of action at system level. Kaemferol, phytosterol and okanin were found to be the important compounds nodes with prominent target nodes of TDP1 and MAPT. CONCLUSION The therapeutic efficiency of Albizia lebbeck in PD was effectively delineated in our experimental and systems pharmacology approach. Moreover, this approach further facilitates the drug discovery from Albizia lebbeck for PD.

中文翻译：

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基于系统药理学的方法来研究阿尔比西亚·莱贝克（L.）在帕金森氏病实验模型中的体内治疗功效。

背景技术帕金森氏病（PD）是一种进行性神经退行性疾病，其特征在于黑质致密部中多巴胺能神经元的丧失，并且在临床上主要表现为运动功能障碍。植物是医学上重要的生物活性化合物的丰富来源，不发达国家的居民将植物用于治疗各种疾病。据报道，Albizia lebbeck具有抗氧化和神经保护特性，这提示了其对神经退行性疾病的传统治疗潜力的评估。本研究的目的是验证Albizia lebbeck（L.）的传统用途并描述其在PD中的作用机制。系统药理学方法用于解释Albizia lebbeck（L.）在PD中的作用机制。方法采用氟哌啶醇致僵直作为PD大鼠实验模型，用于Wistar白化病大鼠的体内研究。系统药理学方法用于解释Albizia lebbeck（L.）在PD中的作用机制。结果体内研究表明，如行为研究所示，白花蛇舌草改善了运动功能和耐力，组织学研究还通过挽救内源性抗氧化剂防御和逆转超微结构损伤进一步支持了运动。系统药理学方法在二分图中确定了25种药物样化合物与132个靶标相互作用，从而揭示了系统级的协同作用机理。发现山茱fer醇，植物甾醇和okanin是重要的化合物结点，其中TDP1和MAPT的目标结点突出。结论在我们的实验和系统药理学方法中有效地描述了白花蛇舌草在PD中的治疗效率。此外，这种方法进一步促进了从Albizia lebbeck研发PD的药物。