Single agent talacotuzumab demonstrates limited efficacy but considerable toxicity in elderly high-risk MDS or AML patients failing hypomethylating agents.,Leukemia

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Single agent talacotuzumab demonstrates limited efficacy but considerable toxicity in elderly high-risk MDS or AML patients failing hypomethylating agents.
Leukemia ( IF 12.8 ) Pub Date : 2019-12-03 , DOI: 10.1038/s41375-019-0645-z
Anne Sophie Kubasch _{1,

2,

3} , Freya Schulze _{2,

3,

4} , Aristoteles Giagounidis _{2,

3,

5} , Katharina S Götze _{2,

3,

6} , Jan Krönke _{2,

3,

7} , Katja Sockel _{2,

3,

4} , Jan Moritz Middeke _{2,

3,

4} , Fatiha Chermat _{3,

8} , Silke Gloaguen _{2,

3} , Martin Puttrich _{3,

9} , Carmen Weigt _{3,

9} , Doreen William _{10,

11} , Pierre Fenaux _{3,

8,

12} , Richard F Schlenk _{3,

11,

13} , Christian Thiede _{3,

4} , Sebastian Stasik _{3,

4} , Anna Mies _{3,

4} , Lionel Adès _{3,

8,

12} , Uta Oelschlägel _{2,

3,

4} , Uwe Platzbecker _{1,

2,

3}

Affiliation

Medical Clinic and Policlinic I, Hematology and Cellular Therapy, Leipzig University Hospital, Leipzig, Germany.
German MDS Study Group (D-MDS), Leipzig, Germany.
The European Myelodysplastic Syndromes Cooperative Group (EMSCO), Leipzig, Germany.
Department of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany.
Department for Oncology, Hematology and Palliative Care, Marien Hospital Düsseldorf, Düsseldorf, Germany.
Department of Medicine III, Klinikum rechts der Isar, TUM, Munich, Germany.
Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany.
Groupe Francophone des Myélodysplasies, Paris, France.
GWT-TUD GmbH, Dresden, Germany.
Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Service d'Hématologie Seniors, Assistance Publique-Hôpitaux de Paris and Paris University, Paris, France.
Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.