Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort.,Molecular Psychiatry

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Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort.
Molecular Psychiatry ( IF 9.6 ) Pub Date : 2019-12-03 , DOI: 10.1038/s41380-019-0621-z
Adrienne L Romer _{1,

2} , Annchen R Knodt _{1,

2} , Maria L Sison ₁ , David Ireland ₃ , Renate Houts ₂ , Sandhya Ramrakha ₃ , Richie Poulton ₃ , Ross Keenan ₄ , Tracy R Melzer _{5,

6} , Terrie E Moffitt _{2,

7,

8,

9} , Avshalom Caspi _{2,

7,

8,

9} , Ahmad R Hariri _{1,

2}

Affiliation

Transdiagnostic research has identified a general psychopathology factor-often called the 'p' factor-that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in serious mental illness. In support of this, we previously used a theory-free, data-driven multimodal neuroimaging approach to find that higher p factor scores are associated with structural alterations within a cerebello-thalamo-cortical circuit (CTCC) and visual association cortex, both of which are important for monitoring and coordinating information processing in the service of executive control. Here we attempt to replicate these associations by conducting region-of-interest analyses using data from 875 members of the Dunedin Longitudinal Study, a five-decade study of a population-representative birth cohort, collected when they were 45 years old. We further sought to replicate a more recent report that p factor scores can be predicted by patterns of distributed cerebellar morphology as estimated through independent component analysis. We successfully replicated associations between higher p factor scores and both reduced gray matter volume of the visual association cortex and fractional anisotropy of pontine white matter pathways within the CTCC. In contrast, we failed to replicate prior associations between cerebellar structure and p factor scores. Collectively, our findings encourage further focus on the CTCC and visual association cortex as core neural substrates and potential biomarkers of general psychopathology.

中文翻译：

与一般精神病理学相关的结构性大脑改变的可重复性：来自具有人口代表性的出生队列的证据。

跨诊断研究已经确定了一个普遍的精神病理学因素——通常称为“p”因素——它解释了不同样本中内化、外化和思维障碍的共同变异。有人认为，p 因素可能反映了严重精神疾病中存在的功能失调的思维。为了支持这一点，我们之前使用了一种无理论、数据驱动的多模态神经影像学方法，发现较高的 p 因子分数与小脑-丘脑-皮质回路 (CTCC) 和视觉关联皮层内的结构改变有关，这两者对于在执行控制服务中监控和协调信息处理非常重要。在这里，我们尝试通过使用来自但尼丁纵向研究的 875 名成员的数据进行感兴趣区域分析来复制这些关联，该研究是一项针对具有人口代表性的出生队列的五年研究，在他们 45 岁时收集。我们进一步试图复制一份更新的报告，即 p 因子分数可以通过独立成分分析估计的分布式小脑形态模式来预测。我们成功地复制了较高的 p 因子得分与 CTCC 内视觉关联皮层灰质体积减少和脑桥白质通路分数各向异性之间的关联。相比之下，我们未能复制小脑结构和 p 因子分数之间的先前关联。集体，

更新日期：2019-12-04

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