Ageing is a multi-factorial condition that results in a gradual decline in tissue and organ function. Systemic, local and intrinsic factors play major roles in this process that also results in a decline in stem cell number and function. In this issue of The EMBO Journal, Li et al (2019) show that a subpopulation of mouse muscle stem cells is depleted in aged mice through loss of niche-derived granulocyte colony-stimulating factor (G-CSF).

中文翻译：

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不稳定的代谢位会引起衰老的肌肉干细胞亚群的丢失。

衰老是导致组织和器官功能逐渐下降的多因素疾病。全身，局部和内在因素在此过程中起主要作用，这也导致干细胞数量和功能下降。Li等人（2019）在此期《 EMBO Journal》中显示，由于失去了利基来源的粒细胞集落刺激因子（G-CSF），老年小鼠的小鼠肌肉干细胞亚群被耗尽。