Multiparametric classification of sub-acute ischemic stroke recovery with ultrafast diffusion, 23 Na, and MPIO-labeled stem cell MRI at 21.1 T.,NMR in Biomedicine

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Multiparametric classification of sub-acute ischemic stroke recovery with ultrafast diffusion, 23 Na, and MPIO-labeled stem cell MRI at 21.1 T.
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2019-12-03 , DOI: 10.1002/nbm.4186
Avigdor Leftin _{1,

2} , Jens T Rosenberg ₃ , Xuegang Yuan ₄ , Teng Ma ₄ , Samuel C Grant _{3,

4} , Lucio Frydman _{1,

4}

Affiliation

MRI leverages multiple modes of contrast to characterize stroke. High-magnetic-field systems enhance the performance of these MRI measurements. Previously, we have demonstrated that individually sodium and stem cell tracking metrics are enhanced at ultrahigh field in a rat model of stroke, and we have developed robust single-scan diffusion-weighted imaging approaches that utilize spatiotemporal encoding (SPEN) of the apparent diffusion coefficient (ADC) for these challenging field strengths. Here, we performed a multiparametric study of middle cerebral artery occlusion (MCAO) biomarker evolution focusing on comparison of these MRI biomarkers for stroke assessment during sub-acute recovery in rat MCAO models at 21.1 T. T2 -weighted MRI was used as the benchmark for identification of the ischemic lesion over the course of the study. The number of MPIO-induced voids measured by gradient-recalled echo, the SPEN measurement of ADC, and 23 Na MRI values were determined in the ischemic area and contralateral hemisphere, and relative performances for stroke classification were compared by receiver operator characteristic analysis. These measurements were associated with unique time-dependent trajectories during stroke recovery that changed the sensitivity and specificity for stroke monitoring during its evolution. Advantages and limitations of these contrasts, and the use of ultrahigh field for multiparametric stroke assessment, are discussed.

中文翻译：

亚急性缺血性卒中恢复的多参数分类，超快扩散，23 Na和MPIO标记的干细胞MRI在21.1T。

MRI利用多种对比模式来表征卒中。高磁场系统增强了这些MRI测量的性能。以前，我们已经证明在大鼠的中风模型中，超高视野下钠和干细胞的单独追踪指标得到了增强，并且我们已经开发了利用表观扩散系数的时空编码（SPEN）的强大的单扫描扩散加权成像方法。（ADC）来应对这些具有挑战性的领域优势。在这里，我们进行了大脑中动脉闭塞（MCAO）生物标志物演变的多参数研究，重点是在大鼠MCAO模型21.1 T亚急性恢复期间比较这些MRI生物标志物用于卒中评估。以T2加权MRI为基准在整个研究过程中确定缺血性病变。在缺血区域和对侧半球中，通过梯度回波测量的MPIO诱导的空隙数量，ADC的SPEN测量和23 Na MRI值，通过接收者操作员特征分析比较了卒中分类的相对性能。这些测量结果与中风恢复期间独特的时间相关轨迹相关，从而改变了中风监测演变过程中的敏感性和特异性。讨论了这些对比的优点和局限性，以及使用超高场进行多参数卒中评估。并通过接收机操作员特征分析比较了笔划分类的相对性能。这些测量结果与中风恢复期间独特的时间相关轨迹相关，从而改变了中风监测演变过程中的敏感性和特异性。讨论了这些对比的优点和局限性，以及使用超高场进行多参数卒中评估。并通过接收机操作员特征分析比较了笔划分类的相对性能。这些测量结果与中风恢复期间独特的时间相关轨迹相关，从而改变了中风监测演变过程中的敏感性和特异性。讨论了这些对比的优点和局限性，以及使用超高场进行多参数卒中评估。

更新日期：2020-01-21

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