BACKGROUND It has been confirmed that the triglyceride to high-density lipoprotein cholesterol ratio (THR) is associated with insulin resistance and metabolic syndrome. However, to the best of our knowledge, only a few studies with small sample sizes have investigated the relationship between THR and coronary artery disease (CAD). Therefore, we aimed to assess the correlation between the THR and long-term mortality in patients with CAD after undergoing percutaneous coronary intervention (PCI) in our study that enrolled a large number of patients. METHODS A total of 3269 post-PCI patients with CAD were enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The mean follow-up time was 37.59 ± 22.24 months. Patients were divided into two groups according to their THR value: the lower group (THR < 2.84, n = 1232) and the higher group (THR ≥ 2.84, n = 2037). The primary endpoint was long-term mortality, including all-cause mortality (ACM) and cardiac mortality (CM). The secondary endpoints were major adverse cardiac events (MACEs) and major adverse cardiac and cerebrovascular events (MACCEs). RESULTS In our study, ACM occurred in 124 patients: 30 (2.4%) in the lower group and 94 (4.6%) in the higher group (P = 0.002). MACEs occurred in 362 patients: 111 (9.0%) in the lower group and 251 (12.3%) in the higher group (P = 0.003). The number of MACCEs was 482: 152 (12.3%) in the lower group and 320 (15.7%) in the higher group (P = 0.008). Heart failure occurred in 514 patients: 89 (7.2%) in the lower group and 425 (20.9%) in the higher group (P < 0.001). Kaplan-Meier analyses showed that elevated THR was significantly related to long-term ACM (log-rank, P = 0.044) and the occurrence of heart failure (log-rank, P < 0.001). Multivariate Cox regression analyses showed that the THR was an independent predictor of long-term ACM (adjusted HR = 2.042 [1.264-3.300], P = 0.004) and heart failure (adjusted HR = 1.700 [1.347-2.147], P < 0.001). CONCLUSIONS An increased THR is an independent predictor of long-term ACM and heart failure in post-PCI patients with CAD.

中文翻译：

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甘油三酸酯/高密度脂蛋白胆固醇比值作为经皮冠状动脉介入治疗后冠状动脉疾病患者长期死亡率的预测指标：一项回顾性队列研究。

背景技术已经证实甘油三酸酯与高密度脂蛋白胆固醇之比（THR）与胰岛素抵抗和代谢综合征有关。然而，据我们所知，只有少数样本量较小的研究调查了THR与冠状动脉疾病（CAD）之间的关系。因此，我们的目的是评估纳入大量患者的经皮冠状动脉介入治疗（PCI）后，冠心病患者的THR与长期死亡率之间的相关性。方法2013年1月至2017年12月，共3269例PCI后冠心病患者入选了CORFCHD-ZZ研究。平均随访时间为37.59±22.24个月。根据患者的THR值将其分为两组：较低的组（THR <2.84，n = 1232）和较高的组（THR≥2.84，n = 2037）。主要终点是长期死亡率，包括全因死亡率（ACM）和心脏死亡率（CM）。次要终点是主要的不良心脏事件（MACE）和主要的不良心脏和脑血管事件（MACCE）。结果在我们的研究中，ACM发生在124例患者中：较低的组30例（2.4％），较高的组94例（4.6％）（P = 0.002）。MACE发生在362例患者中：较低的组为111（9.0％），较高的组为251（12.3％）（P = 0.003）。在较低的组中，MACCE的数量为482：152（12.3％），在较高的组中，MACCE的数量为320（15.7％）（P = 0.008）。514例患者发生心力衰竭：较低的组为89（7.2％），较高的组为425（20.9％）（P <0.001）。Kaplan-Meier分析显示，升高的THR与长期ACM（对数秩，P = 0.044）和心力衰竭的发生（对数秩，P <0.001）显着相关。多变量Cox回归分析显示，THR是长期ACM（校正后的HR = 2.042 [1.264-3.300]，P = 0.004）和心力衰竭（校正后的HR = 1.700 [1.347-2.147]，P <0.001）的独立预测因子。 。结论THR升高是PCI后冠心病患者长期ACM和心力衰竭的独立预测因子。