Background Inflammatory bowel diseases are associated with various immune- and non-immune-mediated conditions. We aimed to assess the association of inflammatory bowel diseases with comorbidities at late adolescence. Methods Jewish Israeli adolescents who underwent a general health evaluation prior to enlistment to the Israeli Defense Forces from 2002 to 2016 were included. Results Overall, 891 subjects (595 Crohn’s disease, 296 ulcerative colitis, median age 17.1 years) and 1,141,841 controls were analyzed. Crohn’s disease was associated with arthritis (odds ratio (OR) 4.7, 95% confidence interval (CI) 2.4–9.1), thyroid disease (OR 2.6, 95% CI 1.2–5.5), atopic dermatitis (OR 2, 95% CI 1.1–3.6), autoimmune hepatitis (OR 4.4, 95% CI 2.3–8.6), nephrolithiasis (OR 3.6, 95% CI 1.2–11.4), and pancreatitis (OR 41.8, 95% CI 17.2–101.9). Ulcerative colitis was associated with arthritis (OR 3.6, 95% CI 1.0–9.8), thyroid disease (OR 4.8, 95% CI 1.2–19.4), autoimmune hepatitis (OR 8, 95% CI 4–16.2), and pancreatitis (OR 51, 95% CI 16.1–158.9). Primary sclerosing cholangitis was associated with both diseases. Asthma, celiac, type 1 diabetes, psoriasis, and bone fractures were not more common in both diseases. Male predominance was noted for most associations. Conclusions At adolescence, both Crohn’s disease and ulcerative colitis are associated with multiple comorbidities, not limited to autoimmune disorders.

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炎症性肠病青少年的合并症：基于人群的队列研究结果

背景炎症性肠病与各种免疫和非免疫介导的疾病有关。我们旨在评估炎症性肠病与青春期晚期合并症的关联。方法 包括在 2002 年至 2016 年加入以色列国防军之前接受一般健康评估的以色列犹太青少年。结果 总共分析了 891 名受试者（595 名克罗恩病，296 名溃疡性结肠炎，中位年龄 17.1 岁）和 1,141,841 名对照。克罗恩病与关节炎（OR 4.7，95% CI 2.4-9.1），甲状腺疾病（OR 2.6，95% CI 1.2-5.5），特应性皮炎（OR 2，95% CI 1.1）相关–3.6)、自身免疫性肝炎 (OR 4.4, 95% CI 2.3–8.6)、肾结石 (OR 3.6, 95% CI 1.2–11.4) 和胰腺炎 (OR 41.8, 95% CI 17.2–101.9)。溃疡性结肠炎与关节炎（OR 3.6，95% CI 1.0-9.8）、甲状腺疾病（OR 4.8，95% CI 1.2-19.4）、自身免疫性肝炎（OR 8，95% CI 4-16.2）和胰腺炎（OR 51, 95% CI 16.1–158.9)。原发性硬化性胆管炎与这两种疾病有关。哮喘、乳糜泻、1 型糖尿病、银屑病和骨折在这两种疾病中并不常见。大多数协会都注意到男性占优势。结论 在青春期，克罗恩病和溃疡性结肠炎都与多种合并症有关，不仅限于自身免疫性疾病。1 型糖尿病、银屑病和骨折在这两种疾病中并不常见。大多数协会都注意到男性占优势。结论 在青春期，克罗恩病和溃疡性结肠炎都与多种合并症有关，不仅限于自身免疫性疾病。1 型糖尿病、银屑病和骨折在这两种疾病中并不常见。大多数协会都注意到男性占优势。结论 在青春期，克罗恩病和溃疡性结肠炎都与多种合并症有关，不仅限于自身免疫性疾病。