Cell-cell fusion is indispensable for creating life and building syncytial tissues and organs. Ever since the discovery of cell-cell fusion, how cells join together to form zygotes and multinucleated syncytia has remained a fundamental question in cell and developmental biology. In the past two decades, Drosophila myoblast fusion has been used as a powerful genetic model to unravel mechanisms underlying cell-cell fusion in vivo. Many evolutionarily conserved fusion-promoting factors have been identified and so has a surprising and conserved cellular mechanism. In this review, we revisit key findings in Drosophila myoblast fusion and highlight the critical roles of cellular invasion and resistance in driving cell membrane fusion.

中文翻译：

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果蝇成肌细胞融合：终极联盟的入侵与抵抗。

细胞与细胞的融合对于创造生命和构建合体组织和器官是必不可少的。自从发现细胞与细胞融合以来，细胞如何结合在一起形成受精卵和多核合胞体一直是细胞和发育生物学中的一个基本问题。在过去的二十年中，果蝇成肌细胞融合已被用作强大的遗传模型来揭示体内细胞与细胞融合的机制。许多进化上保守的融合促进因子已被鉴定，因此具有令人惊讶且保守的细胞机制。在这篇综述中，我们重新审视了果蝇成肌细胞融合的关键发现，并强调了细胞侵袭和抵抗在驱动细胞膜融合中的关键作用。