AIMS While there is plentiful evidence on elevated serum levels of amylase, lipase, and trypsin in acute illness, low serum levels of these digestive enzymes have been studied infrequently. The aim was to systematically review published studies on the relationship between low serum levels of amylase, lipase, or trypsin and metabolic disorders. METHODS The search was conducted in MEDLINE and Scopus databases. Studies in humans were included if they reported on the association between serum levels of amylase, lipase, or trypsin within normal range and metabolic disorders. Random-effects meta-analysis was conducted. RESULTS A total of 20 studies encompassing 20,916 participants were included. Compared with healthy individuals, individuals with type 2 diabetes mellitus (mean difference = -5.3; p < 0.001), metabolic syndrome (mean difference = -5.1; p < 0.001), and overweight/obesity (mean difference = -0.8; p = 0.02) had significantly lower serum levels of amylase. Both individuals with type 1 diabetes mellitus (mean difference = -1.8; p < 0.001) and type 2 diabetes mellitus (mean difference = -0.8; p < 0.001) had significantly lower serum levels of lipase compared with healthy individuals. Data on serum trypsin were not suitable for meta-analysis. In the pooled analysis, individuals with type 2 diabetes mellitus had 3.1-times lower serum levels of amylase, 2.9-times lower serum levels of lipase, and 2.5-times lower serum levels of trypsin levels than the upper limits of normal for the three digestive enzymes. CONCLUSION Low serum levels of amylase and lipase are significantly associated with type 2 diabetes mellitus, type 1 diabetes mellitus, excess adiposity, and metabolic syndrome. The role of digestive enzymes in the pathogenesis of metabolic disorders warrants further investigations.

中文翻译：

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低血清淀粉酶，脂肪酶和胰蛋白酶作为代谢紊乱的生物标志物：系统评价和荟萃分析。

目的尽管有大量证据表明在急性疾病中血清淀粉酶，脂肪酶和胰蛋白酶的水平升高，但很少对这些消化酶的血清水平进行研究。目的是系统地回顾已发表的有关低血清淀粉酶，脂肪酶或胰蛋白酶与代谢紊乱之间关系的研究。方法在MEDLINE和Scopus数据库中进行搜索。如果他们报告了正常范围内的血清淀粉酶，脂肪酶或胰蛋白酶水平与代谢紊乱之间的关系，则包括对人体的研究。进行随机效应荟萃分析。结果共纳入20项研究，涉及20,916名参与者。与健康个体相比，患有2型糖尿病（平均差异= -5.3； p <0.001），代谢综合征（平均差异= -5）的个体。1; p <0.001）和超重/肥胖（平均差异= -0.8； p = 0.02）明显降低了淀粉酶的血清水平。与健康个体相比，患有1型糖尿病（均值= -1.8； p <0.001）和2型糖尿病（均值= -0.8； p <0.001）的人的脂肪酶血清水平明显降低。血清胰蛋白酶的数据不适合进行荟萃分析。在汇总分析中，与3种消化系统正常值的上限相比，患有2型糖尿病的人的淀粉酶血清水平降低了3.1倍，脂肪酶血清水平降低了2.9倍，胰蛋白酶水平降低了2.5倍。酶。结论血清淀粉酶和脂肪酶水平低与2型糖尿病，1型糖尿病，肥胖，和代谢综合征。消化酶在代谢紊乱的发病机理中的作用值得进一步研究。