Cells in epithelial tissues utilize homotypic E-cadherin interaction-mediated adhesions to both physically adhere to each other and sense the physical properties of their microenvironment, such as the presence of other cells in close vicinity or an alteration in the mechanical tension of the tissue. These position E-cadherin centrally in organogenesis and other processes, and its function is therefore tightly regulated through a variety of means including endocytosis and gene expression. How does membrane molecular mobility of E-cadherin, and thus membrane physical properties and associated actin cytoskeleton, impinges on the assembly of adhesive clusters and signaling is discussed.

中文翻译：

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E-钙黏着蛋白粘附的分子迁移率调节。

上皮组织中的细胞利用同型E-钙粘蛋白相互作用介导的粘附力彼此物理粘附，并感知其微环境的物理特性，例如附近存在其他细胞或组织机械张力发生改变。这些E-钙粘着蛋白在器官发生和其他过程中处于中心位置，因此其功能通过包括内吞作用和基因表达在内的多种手段受到严格调节。讨论了E-钙粘着蛋白的膜分子迁移率以及膜的物理特性和相关的肌动蛋白细胞骨架如何影响粘合剂簇的组装和信号传导。