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The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach.
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2019-12-03 , DOI: 10.1002/ejhf.1674
Martijn F Hoes 1 , Jasper Tromp 1, 2, 3 , Wouter Ouwerkerk 2, 4 , Nils Bomer 1 , Silke U Oberdorf-Maass 1 , Nilesh J Samani 5 , Leong L Ng 5 , Chim C Lang 6 , Pim van der Harst 1 , Hans Hillege 1 , Stefan D Anker 7, 8, 9 , Marco Metra 10 , Dirk J van Veldhuisen 1 , Adriaan A Voors 1 , Peter van der Meer 1
Affiliation  

Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown. The aim of this study is to determine the association between circulating cathepsin D levels and clinical outcomes in patients with HF and to investigate the biological settings that induce the release of cathepsin D in HF.

中文翻译:

组织蛋白酶D在心力衰竭的病理生理中的作用及其潜在的有益特性:一种翻译方法。

组织蛋白酶D是一种普遍存在的溶酶体蛋白酶,主要由于氧化应激而分泌。循环组织蛋白酶D在心力衰竭(HF)中的作用尚不清楚。这项研究的目的是确定循环组织蛋白酶D水平与HF患者的临床结局之间的关系,并研究诱导组织蛋白酶D在HF中释放的生物学环境。
更新日期:2019-12-03
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