Dopamine loss beyond the mesostriatal system might be relevant in pathogenic mechanisms and some clinical manifestations in PD. The primate thalamus is densely and heterogeneously innervated with dopaminergic axons, most of which express the dopamine transporter, as does the nigrostriatal system. We hypothesized that dopamine depletion may be present in the thalamus of the parkinsonian brain and set out to ascertain possible regional differences.

中文翻译：

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猴子进行性帕金森病模型中丘脑多巴胺神经支配的变化

跨纹状体系统的多巴胺损失可能与 PD 的致病机制和一些临床表现有关。灵长类丘脑由多巴胺能轴突密集而异质地支配，其中大部分表达多巴胺转运蛋白，黑质纹状体系统也是如此。我们假设帕金森病大脑的丘脑中可能存在多巴胺耗竭，并着手确定可能的区域差异。